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PI 3-kinase p110beta: a new target for antithrombotic therapy.
Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however, excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the… Expand
Analysis of competitive agonist-antagonist interactions by nonlinear regression.
The rigorous estimation of a dissociation constant (Kb) for antagonists in functional assays has been sought by pharmacologists using a variety of techniques ever since the regression method of… Expand
Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.
Agents which decrease conductance of N-type voltage-gated Ca(2+) channels have been shown to attenuate measures of neuropathic pain in animal models and to provide symptom relief in humans. The… Expand
Pharmacology of coronary artery bypass grafts.
Spasm of arterial and venous graft conduits can occur both during harvesting and after the graft is connected. Attempts to overcome spasm during harvesting by probing or hydraulic distension can… Expand
Analyzing head-related transfer function measurements using surface spherical harmonics
A continuous, functional representation of a large set of head-related transfer function measurements (HRTFs) is developed. The HRTFs are represented as a weighted sum of surface spherical harmonics… Expand
Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin
Arteries relax to the vasodilators acetylcholine, substance P, ATP and bradykinin only if the endothelium is present1–4. One hypothesis is that these substances stimulate the endothelial cells to… Expand
Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting.
Spasm of the saphenous vein frequently occurs during harvesting from the leg and high-pressure distension is required to restore an adequate diameter for grafting. Forceful distention has been shown… Expand
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
&NA; The roles of the two cannabinoid receptor subtypes, CB‐1 and CB‐2, have not been clarified in cannabinoid‐mediated analgesia. We investigated the efficacy of the non‐selective cannabinoid… Expand
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with μ opioid receptor and α2‐adrenoceptor agonists in acute pain models in mice
- Shao M Tham, J. Angus, E. Tudor, C. Wright
- Chemistry, Medicine
- British journal of pharmacology
- 1 March 2005
1 Cannabinoid receptor agonists elicit analgesic effects in acute and chronic pain states via spinal and supraspinal pathways. We investigated whether the combination of a cannabinoid agonist with… Expand
Reactivity of the Canine Isolated Internal Mammary Artery, Saphenous Vein, and Coronary Artery to Constrictor and Dilator Substances: Relevance to Coronary Bypass Graft Surgery
The internal mammary artery (IMA) and saphenous vein (SV) are used routinely in coronary artery (CA) bypass graft surgery. The IMA may develop spasm during surgery, and the SV often develops spasm… Expand