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The Developmental Transcriptome of Drosophila melanogaster
Drosophila melanogaster is one of the most well studied genetic model organisms, nonetheless its genome still contains unannotated coding and non-coding genes, transcripts, exons, and RNA editingExpand
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Diversity and dynamics of the Drosophila transcriptome
Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing an ensemble of transcript isoforms that give rise to substantial diversity. Here we have identified newExpand
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Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function
BackgroundDiscovering the functions of all genes is a central goal of contemporary biomedical research. Despite considerable effort, we are still far from achieving this goal in any metazoanExpand
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DNA copy number evolution in Drosophila cell lines
BackgroundStructural rearrangements of the genome resulting in genic imbalance due to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines andExpand
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Gene discovery in the horned beetle Onthophagus taurus
BackgroundHorned beetles, in particular in the genus Onthophagus, are important models for studies on sexual selection, biological radiations, the origin of novel traits, developmental plasticity,Expand
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Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines.
We expanded the knowledge base for Drosophila cell line transcriptomes by deeply sequencing their small RNAs. In total, we analyzed more than 1 billion raw reads from 53 libraries across 25 cellExpand
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Profiling sex-biased gene expression during parthenogenetic reproduction in Daphnia pulex
BackgroundSexual reproduction is a core biological function that is conserved throughout eukaryotic evolution, yet breeding systems are extremely variable. Genome-wide comparative studies can beExpand
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Mediation of Drosophila autosomal dosage effects and compensation by network interactions
BackgroundGene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold lessExpand
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Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells
BackgroundGermline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility andExpand
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EST and microarray analysis of horn development in Onthophagus beetles
BackgroundThe origin of novel traits and their subsequent diversification represent central themes in evo-devo and evolutionary ecology. Here we explore the genetic and genomic basis of a class ofExpand
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