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Maternal administration of granulocyte colony-stimulating factor improves neonatal rat survival after a lethal group B streptococcal infection
TLDR
It is demonstrated that maternal administration of rhG- CSF augments neonatal defenses against a lethal bacterial challenge.
In vivo analysis of castanospermine, a candidate antiretroviral agent.
TLDR
It is concluded that castanospermine is an active antiviral agent in animals and that prolonged oral administration is tolerable; however, when compared to 3'-azido-3'-deoxythymidine in the same murine system, castanos permine was less active and more toxic.
Oral transmission of primate lentiviruses.
TLDR
To study oral virus transmission in primate models, rhesus macaques of various ages are exposed to cell-free simian immunodeficiency virus (SIV), including uncloned and molecularly cloned viruses, which have implications for the risks of HIV-1 transmission during oral-genital contact.
New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat
TLDR
The results demonstrate that the antipneumocystis activities of the pneumocandins can be significantly improved through synthetic modification, making them attractive as broad-spectrum antifungal agents.
Oral SIV, SHIV, and HIV type 1 infection.
TLDR
After nontraumatic inoculation, the oral route was more efficient than the rectal route in permitting SIV entry in adult macaques, indicating that oral exposure to various virus strains, including T cell-tropic variants, leads to infection.
Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones.
TLDR
Measurements of urinary recoveries of urease inhibitory activity following administration of flurofamide indicate that efficacy might be achieved in humans at doses under 1mg./kg, and the compound is effective in retarding stone formation in the urinary tract of rats infected with P. mirabilis.
Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes.
TLDR
RhEPO has a role in the treatment of certain patients with MDS, particularly in those whose endogenous serum erythropoietin levels are not markedly elevated, and was the best predictor of hemoglobin response when controlling for other variables.
Maternal administration of granulocyte colony-stimulating factor improves neonatal rat survival after a lethal group B streptococcal infection.
TLDR
It is demonstrated that maternal administration of rhG-CSF augments neonatal defenses against a lethal bacterial challenge.
Preliminary Experience with Amlodipine in the Pediatric Population
TLDR
Given its efficacy, the low incidence of adverse effects, and availability as a suspension, amlodipine is an effective agent for the treatment of hypertension in the pediatric-aged patient.
Benurestat, a urease inhibitor for the therapy of infected ureolysis.
TLDR
Some combination therapies composed of benurestat plus an antibacterial agent, sulfamethoxazole or ampicillin, were effective in promoting the net dissolution of formed calculi.
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