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Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone.
TLDR
T therapy in older men with low serum testosterone levels increases vertebral and hip BMD over 36 months, both when administered alone and when combined with F, and suggests that dihydrotestosterone is not essential for the beneficial effects of T on BMD in men. Expand
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation
TLDR
The effects of human ALDH isoenzymes, ALDH1A2 and ALDH2, on drug resistance and proliferation, and the specificity of DEAB as an inhibitor are explored, concluding that DEAB is not a specific inhibitor for AL DH1A1 and that Aldefluor assay is not specific for ALDH 1A1 activity. Expand
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.
TLDR
It is demonstrated that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation. Expand
TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood.
TLDR
Although the neurokinin B pathway appears essential during early sexual development, its importance in sustaining the integrity of the hypothalamic-pituitary-gonadal axis appears attenuated over time. Expand
A History of the Birth Control Movement in America
This narrative history of one of the most far-reaching social movements in the 20th century shows how it defied the law and made the use of contraception an acceptable social practice-and a necessaryExpand
Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
TLDR
Testosterone supplementation may benefit selective cognitive functions in men with Alzheimer disease and mild cognitive impairment. Expand
Persistent intraprostatic androgen concentrations after medical castration in healthy men.
TLDR
Despite a 94% decrease in serum T with medical castration, intraprostatic T and dihydrotestosterone levels remained 20-30% of control values, and prostate cell proliferation, apoptosis, and androgen-regulated protein expression were unaffected, highlighting the importance of assessing tissue hormone levels. Expand
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism
TLDR
DNA screened DNA from 310 patients with normosmic IHH (nIHH) and 192 healthy control subjects for sequence changes in GNRH1 and establish mutations in GN RH1 as a genetic cause of nIHH. Expand
Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.
TLDR
It is demonstrated that T therapy in older men with low serum T improves physical performance and strength over 36 months, when administered alone or when combined with F, and suggested that high serum levels of dihydrotestosterone are not essential for these beneficial effects of T in men. Expand
Are physicians aware of which of their patients have indwelling urinary catheters?
TLDR
Physicians are commonly unaware that their patients have an indwelling urinary catheter, and system-wide interventions aimed at discontinuing unnecessary catheterization seem warranted. Expand
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