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Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut
TLDR
The proposed KV is a transient embryonic `organ of asymmetry' that directs LR development by establishing a directional fluid flow and genetic analysis reveals novel roles for the T-box transcription factor no tail and the Nodal signaling pathway as upstream regulators of lrdr1 expression and KV morphogenesis.
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FGF signalling during embryo development regulates cilia length in diverse epithelia
TLDR
This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plague” found in the immune system.
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The T Box Transcription Factor No Tail in Ciliated Cells Controls Zebrafish Left-Right Asymmetry
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Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish.
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CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base
TLDR
CEP162 is thus an axoneme-recognition protein pre-tethered at centriole distal ends before ciliogenesis to promote and restrict transition zone formation specifically at the cilia base.
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Cis and trans effects of the myotonic dystrophy (DM) mutation in a cell culture model.
TLDR
Evidence is provided that the DM mutation acts in cis to reduce protein production (consistent with DMPK haploinsufficiency) and in trans as a 'riboregulator' to inhibit myogenesis.
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FGF Signaling during embryo development regulates cilia length in diverse epithelia
TLDR
Several lines of evidence are provided showing that fibroblast growth factor (FGF) signalling regulates cilia length and function in diverse epithelia during zebrafish and Xenopus development and proposing that a subset of developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function.
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The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation.
TLDR
RNA foci formation, and perturbation of any RNA binding factors involved in this process, are not sufficient to block myoblast differentiation, and it is found that transcripts containing expanded CUG tracts can form both nuclear and cytoplasmic RNA foci.
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The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish
TLDR
A Rho kinase gene, rock2b, is identified, which is required for normal AP patterning of KV and subsequent LR development in the embryo, and a link between AP patterned of the ciliated Kupffer's vesicle and LR patterner of the zebrafish embryo is suggested.
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Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport
TLDR
It is proposed that Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde IFT, thereby promoting ciliogenesis in mammalian cells.
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