Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons
- J. Allen, G. Shanker, M. Aschner
- Biology, Medicine
- Brain Research
- 9 March 2001
Maintenance of adequate intracellular glutathione (GSH) levels is vital for intracellular defense against oxidative damage. The toxic effects of methylmercury (MeHg) are attributable, at least in… Expand
Methylmercury-mediated inhibition of 3H-d-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase
- J. Allen, L. Mutkus, M. Aschner
- Chemistry, Medicine
- Brain Research
- 25 May 2001
Astrocytes are essential for removal of glutamate from the extracellular space in the central nervous system. The neurotoxic heavy metal methylmercury potently and specifically inhibits the transport… Expand
Methylmercury alters glutamate transport in astrocytes
- M. Aschner, C. P. Yao, J. Allen, K. Tan
- Chemistry, Medicine
- Neurochemistry International
- 1 August 2000
Methylmercury (MeHg) is a significant environmental contaminant that will continue to pose great risk to human health. Considerable attention in the scientific and health policy fora is focused on… Expand
The uptake of cysteine in cultured primary astrocytes and neurons
- G. Shanker, J. Allen, L. Mutkus, M. Aschner
- Biology, Medicine
- Brain Research
- 1 June 2001
One of the vitally important functions of glutathione (GSH) is to adequately protect cells against toxic chemicals, reactive oxygen metabolites and free radical species. The amino acid, cysteine, is… Expand
Favorable early results of gastric banding for morbid obesity: the American experience
Background: In 2001 a new device for surgical weight loss was approved by the Food and Drug Administration (Lap-Band, Inamed Health). We describe initial results of laparoscopic gastric banding for… Expand
The consequences of methylmercury exposure on interactive functions between astrocytes and neurons.
- J. Allen, G. Shanker, K. Tan, M. Aschner
- Chemistry, Medicine
- Neurotoxicology
- 1 December 2002
Methylmercury (MeHg) is a highly neurotoxic, environmentally ubiquitous chemical that exerts its toxic effects by largely unknown mechanisms. Maintenance of optimal intracellular concentrations of… Expand
Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes
- J. Allen, L. Mutkus, M. Aschner
- Chemistry, Medicine
- Brain Research
- 9 February 2001
Methylmercury (MeHg) is highly neurotoxic with an apparent dose-related latency period between time of exposure and the appearance of symptoms. Astrocytes are known targets for MeHg toxicity and a… Expand
Article Commentary: Complications of Bariatric Surgery: Implications for the Covering Physician
- Benjamin D. Tanner, J. Allen
- Medicine
- The American surgeon
- 1 February 2009
Bariatric surgery is the only effective option for sustained weight loss for morbidly obese patients. The increasing prevalence of obesity in America and the application of a laparoscopic approach to… Expand
Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor‐dependent neuronal cell death and caspase‐3‐dependent apoptosis
- J. Allen, S. Knoblach, A. Faden
- Medicine
- FASEB journal : official publication of the…
- 1 October 1999
Neuronal necrosis and apoptosis occur after traumatic brain injury (TBI) in animals and contribute to subsequent neurological deficits. In contrast, relatively little apoptosis is found after… Expand
Ethanol-induced swelling in neonatal rat primary astrocyte cultures
- M. Aschner, J. Allen, L. Mutkus, Cheng-Chen Cao
- Chemistry, Medicine
- Brain Research
- 11 May 2001
We tested the hypothesis that astrocytes swell in response to ethanol (EtOH) exposure. The experimental approach consisted of an electrical impedance method designed to measure cell volume. In… Expand