J. Alexander

Publications31
h-index13
Citations670
Highly Influential Citations18
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Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice.
Porous silicon (pSi) is emerging as a promising material in the development of nanovectors for the systemic delivery of therapeutic and imaging agents. The integration of photolithographic… Expand
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A physical sciences network characterization of non-tumorigenic and metastatic cells
  • David B. Jenolyn F. Wadih Shashanka Joseph E. Robert H. Agus Alexander Arap Ashili Aslan Austin Backman Be, D. B. Agus, +93 authors Pei-Hsun Wu
  • Biology, Medicine
  • Scientific reports
  • 26 April 2013
To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed molecular and biophysical… Expand
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Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases.
Current treatments for liver metastases arising from primary breast and lung cancers are minimally effective. One reason for this unfavorable outcome is that liver metastases are poorly vascularized,… Expand
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Cubical Shape Enhances the Interaction of Layer-by-Layer Polymeric Particles with Breast Cancer Cells.
Blood-borne objects display a nonspherical shape with in-flow dimensions much larger than the vascular endothelial fenestrations, yet, at the diseased state, are able to traverse through these… Expand
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Internalization of Red Blood Cell-Mimicking Hydrogel Capsules with pH-Triggered Shape Responses
We report on naturally inspired hydrogel capsules with pH-induced transitions from discoids to oblate ellipsoids and their interactions with cells. We integrate characteristics of erythrocytes such… Expand
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Liposomes: a nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model.
OBJECTIVE Indomethacin (IND) is a prostaglandin production inhibitor that reduces uterine contractions, but crosses the placenta leading to adverse fetal effects. Liposomes (LIP) are nanoscale… Expand
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Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma.
The mechanism for improved therapeutic efficacy of the combination therapy with nanoparticle albumin-bound paclitaxel (nAb-PTX) and gemcitabine (gem) for pancreatic ductal adenocarcinoma (PDAC) has… Expand
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Mass Transport via Cellular Barriers and Endocytosis
Mass transport within body compartments and across biological barriers negatively impacts drug delivery but also presents opportunities to optimally design drug carriers that benefit from novel… Expand
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The Plasma Ion and Electron Instruments for the Genesis Mission
The Genesis Ion Monitor (GIM) and the Genesis Electron Monitor (GEM) provide 3-dimensional plasma measurements of the solar wind for the Genesis mission. These measurements are used onboard to… Expand
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Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond.
Cell-based therapy is emerging as a promising strategy for treating a wide range of human diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and several types of… Expand
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