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Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat.
TLDR
The urinary excretion of HNE in the rat and the nature of metabolites formed are examined, showing that no unchanged parent compound was detected in urine whereas at least four metabolites were present, most of them corresponding to mercapturic acid conjugates.
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Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways.
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Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat.
TLDR
HNE-GSH is the most likely candidate for the formation of omega-hydroxylated HNE-mercapturic acid conjugates excreted in rat urine.
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Identification of novel urinary metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in rats.
Following iv administration of 4-hydroxy-2-nonenal (HNE) and [4-3H]HNE to rats, 15 polar urinary metabolites accounting for about 50% of the urinary radioactivity were separated by HPLC. Among them,…
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Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat precision-cut liver slices.
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[Symptoms of human trypanosomiasis at the first diagnostic phase in the People Republic of Congo (author's transl)].
TLDR
The authors demonstrate that thesymptomatology of the woman is richer than that of the man and several symptoms are closely related to age and the precocity of nervous signs which often are shown by patients without any disturbance of C.S.F.
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Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: evidence of enterohepatic circulation of these byproducts of lipid peroxidation.
TLDR
Five metabolites were present in the bile of rats following a single iv administration of [4-(3)H]HNE and the potential for enterohepatic recycling of HNE metabolites were investigated, suggesting that intestinal microflora and/or intestinal mucosa could biotransform HNE-related compounds before or during the reabsorption process.
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Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation.
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Mechanism of cadmium-decreased glucuronidation in the rat.
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Metabolism and Cytotoxicity of Chlorpropham (CIPC) and Its Essential Metabolites in Isolated Rat Hepatocytes During a Partial Inhibition of Sulphation and Glucuronidation Reactions: A Comparative…
TLDR
A combined effect of free 4-OH CIPC and D-galactosamine on intracellular ATP level that could account for the partial inhibition of sulphation is demonstrated.
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