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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.
TLDR
The gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers and nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Expand
An integrated catalog of reference genes in the human gut microbiome
TLDR
The integrated gene catalog (IGC) is established comprising 9,879,896 genes, which includes close-to-complete sets of genes for most gut microbes, which are also of considerably higher quality than in previous catalogs. Expand
Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders
TLDR
Using whole-exome sequencing in combination with network analysis, 18 previously unknown putative HSP genes are identified and validated and link HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease. Expand
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
TLDR
Altered alterations in the gut, dental or saliva microbiome distinguished individuals with RA from healthy controls, were correlated with clinical measures and could be used to stratify individuals on the basis of their response to therapy. Expand
Mutations in the Pre-Replication Complex cause Meier-Gorlin syndrome
TLDR
It is reported here that individuals with this disorder show marked locus heterogeneity, and mutations in five separate genes are identified: ORC1, ORC4,ORC6, CDT1 and CDC6, implicating defects in replication licensing as the cause of a genetic syndrome with distinct developmental abnormalities. Expand
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
TLDR
It is suggested that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma and high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. Expand
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
TLDR
The first metagenomic profiling study of CRC faecal microbiomes is presented to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology. Expand
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
TLDR
The observed effect sizes are several times larger than any previous findings in large-scale genome-wide association studies of these traits and constitute further proof of the value of conducting genetic association studies outside the traditional setting of large homogeneous populations. Expand
Meier–Gorlin syndrome genotype–phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis
TLDR
Genotype–phenotype studies in 45 individuals with Meier–Gorlin syndrome found growth hormone and estrogen treatment may be of some benefit, respectively, to growth retardation and breast hypoplasia, though further studies in this patient group are needed. Expand
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