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The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism
An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how eachExpand
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A Distinct Nuclear Import Pathway Used by Ribosomal Proteins
Protein transport into the nucleus is governed by the interaction of soluble transport factors with their import substrates and nuclear pore complexes. Here, we identify a major distinct nuclearExpand
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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screeningExpand
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Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
A cytosolic yeast karyopherin, Kap104p, was isolated and shown to function in the nuclear import of a specific class of proteins. The protein bound directly to repeat-containing nucleoporins and to aExpand
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Peroxisomes take shape
Peroxisomes carry out various oxidative reactions that are tightly regulated to adapt to the changing needs of the cell and varying external environments. Accordingly, they are remarkably fluid andExpand
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Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Posttranslational histone modifications participate in modulating the structure and function of chromatin. Promoters of transcribed genes are enriched with K4 trimethylation and hyperacetylation onExpand
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Words in the mind
A stationary offshore platform is protected against damage from moving ice sheets by a conical shield surrounding the platform support structure and having means, such as a pneumatic biasing system,Expand
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Comprehensive analysis of diverse ribonucleoprotein complexes
The study of the dynamic interactome of cellular ribonucleoprotein (RNP) particles has been hampered by severe methodological limitations. In particular, the affinity purification of intact RNPExpand
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Proteomic and genomic characterization of chromatin complexes at a boundary
We have dissected specialized assemblies on the Saccharomyces cerevisiae genome that help define and preserve the boundaries that separate silent and active chromatin. These assemblies containExpand
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Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p
We have taken a combined genetic and biochemical approach to identify major constituents of the yeast nuclear pore complex (NPC). A synthetic lethal screen was used to identify proteins whichExpand
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