• Publications
  • Influence
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
TLDR
It is shown that the ATM protein kinase directly phosphorylates T68 within the SQ/TQ-rich domain of Chk2 in vitro and that T68 is phosphorylated in vivo in response to IR in an ATM-dependent manner.
Molecular properties of the proteasome activator PA28 family proteins and γ‐interferon regulation
TLDR
This work has implicated an important role for PA28 in the major histocompatibility complex (MHC) class I‐restricted antigen processing pathway and an immunomodulatory cytokine γ‐interferon (γ‐IFN) was found to increase greatly the messages forPA28α and PA28β, but not Ki antigen, in human cells.
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
TLDR
It is demonstrated that NS3 protein could specifically repress the promoter activity of p21 in a dose-dependent manner and the growth rate of NS3-expressing cell lines was at least twice as fast as that of the parent NIH 3T3 cells, indicating that the repression of p 21 is actually reflected by the stimulation of cell growth.
Isolation and culture of bovine mammary epithelial cells and establishment of gene transfection conditions in the cells.
TLDR
The transfection efficiency of BMEC by the calcium phosphate method was greatly improved by post-transfection osmotic shock with glycerol or polyethylene glycol, and an about 700 bp DNA fragment containing 5'-flanking sequence of bovine alpha s1-casein gene showed promoter activity in the transfected BMEC.
Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. An essential residue in catalysis.
TLDR
The mutant enzymes containing Glu, Gly, Met, Ser, or Tyr at position 130, as well as the wild-type human GDH encoded by the synthetic gene, were efficiently expressed as a soluble protein and are indistinguishable from that isolated from human and bovine tissues.
Magnetic separation: a highly effective method for synchronization of cultured erythrocytic Plasmodium falciparum
TLDR
The results of this study showed that the magnetic method effectively synchronized and concentrated P. falciparum with finer demarcation capacity in the erythrocytic asexual cycle of the parasite than currently available synchronization methods.
cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.
TLDR
It is shown that CREB3L1 is required for decidualization in mice and humans and may be linked to the pathogenesis of endometriosis in a P4-dependent manner.
...
1
2
3
...