Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.
It is shown that CTGF inhibits BMP and activates TGF-beta signals by direct binding in the extracellular space and can antagonize BMP4 activity by preventing its binding to BMP receptors and has the opposite effect, enhancement of receptor binding, on TGF 1.
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
Results show that CTGF inhibits BMP and activates TGF-β signals by direct binding in the extracellular space and can antagonize BMP4 activity by preventing its binding to BMP receptors and has the opposite effect, enhancement of receptor binding, on T GF-β1.
Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies
It is reported that Wnt signaling is governed by phosphorylation regulation of the Axin scaffolding function, which reveals mechanisms for scaffold regulation and morphogen signaling.
Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
This model provides a possible mechanism to account for inhibition of β-catenin phosphorylation by Wnt-activated LRP6, and shows that a phosphorylated PPPSPXS peptide is able to activate Wnt/β- catenin signaling and to induce axis duplication in Xenopus embryos, presumably by inhibition of GSK3 in vivo.
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development
Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes β-catenin cellular localization
- Nathalia Amado, Débora M Cerqueira, F. S. Menezes, J. F. Mendes da Silva, V. M. Neto, J. Abreu
- Biology, MedicineAnti-Cancer Drugs
- 1 August 2009
Data show that isoquercitrin reduces Gbm cell growth without inducing apoptosis, possibly by modulating the control of the cell cycle, and suggest that &bgr;-catenin-mediated signaling may be involved on the antiproliferative activity of isoquERCitrin.
Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer.
Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies
- Nathalia Amado, D. Predes, Marcela M. Moreno, Igor O. Carvalho, F. Mendes, J. Abreu
- BiologyInternational Journal of Molecular Sciences
- 1 July 2014
The role of flavonoids, a class of natural compounds, on Wnt/β-catenin regulation and its possible potential for therapeutic usage on colorectal cancer is discussed.