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Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
The crystal structure of bovine mitochondrial F1-ATPase determined at 2.8 Å resolution supports a catalytic mechanism in intact ATP synthase in which the three catalytic subunits are in different states of the catalytic cycle at any instant. Expand
Methods used in the structure determination of bovine mitochondrial F1 ATPase.
The F(1) ATPase particle is the largest asymmetric structure solved to date and the most important feature is that the electron density in the solvent region is inverted rather than set to a constant value, as in conventional solvent flattening. Expand
The anticoagulant activation of antithrombin by heparin.
A clear definition of the binding site will provide a structural basis for developing heparin analogues that are more specific toward their intended target antithrombin and therefore less likely to exhibit side effects. Expand
Importance of Nuclear Localization of Apoptin for Tumor-specific Induction of Apoptosis*
It is shown that Apoptin contains two different domains that induce apoptosis independently, and for both domains, a strong correlation between localization and killing activity is found, which increases the understanding of the molecular pathway of Ap optin and may also shed light on the mechanism of cellular transformation. Expand
ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase
Two high-resolution NMR structures are reported of the 213-residue nucleotide-binding domain of rat α1 Na,K-ATPase, determined in the absence and the presence of ATP, showing the low-affinity ATP-binding state. Expand
Prediction of RNA secondary structure, including pseudoknotting, by computer simulation.
A computer program is presented which determines the secondary structure of linear RNA molecules by simulating a hypothetical process of folding. This process implies the concept of 'nucleationExpand
The crystal structure of the nucleotide-free α3β3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer
The structures of the bacterial F 1 -ATPase α and β subunits are very similar to their counterparts in the mitochondrial enzyme, suggesting a common catalytic mechanism. Expand
Five pseudoknots are present at the 204 nucleotides long 3' noncoding region of tobacco mosaic virus RNA.
The results show that the three-dimensional folding of the 3' non-translated region of tobamoviral RNAs is largely maintained by the formation of five pseudoknots, which suggests that recombinational events among aminoacylatable plant viral RNAs have to be considered. Expand
Structure of the E. coli signal recognition particle bound to a translating ribosome
The structures reveal the regions that are involved in complex formation, provide insight into the conformation of the SRP on the ribosome and indicate the conformational changes that accompany high-affinity SRP binding to ribosomes nascent chain complexes upon recognition of the signal sequence. Expand
CRANK: new methods for automated macromolecular crystal structure solution.
CRANK is a novel suite for automated macromolecular structure solution and uses recently developed programs for substructure detection, refinement, and phasing. CRANK utilizes methods forExpand