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The tomato genome sequence provides insights into fleshy fruit evolution
A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome. Expand
c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress
This work describes the isolation and characterization of LTA-deficient S. aureus suppressor strains that regained the ability to grow almost normally in the absence of this cell wall polymer, and demonstrates that GdpP functions in vivo as a c-di-AMP-specific phosphodiesterase, as intracellular c-Di-AMP levels increase drastically in gdpP deletion strains and in an LTA -deficient suppressor strain. Expand
Genome Expansion and Gene Loss in Powdery Mildew Fungi Reveal Tradeoffs in Extreme Parasitism
A group of papers analyzes pathogen genomes to find the roots of virulence, opportunism, and life-style determinants in plant pathogens, suggesting that most effectors represent species-specific adaptations. Expand
Structure and evolution of barley powdery mildew effector candidates
It is hypothesized that the associated genes originated from an ancestral gene, encoding a secreted ribonuclease, duplicated successively by repetitive DNA-driven processes and diversified during the evolution of the grass and cereal powdery mildew lineage. Expand
WebACT - an online companion for the Artemis Comparison Tool
UNLABELLED WebACT is an online resource which enables the rapid provision of simultaneous BLAST comparisons between up to five genomic sequences in a format amenable for visualization with theExpand
A Snapshot of the Emerging Tomato Genome Sequence
This first snapshot of the emerging tomato genome and its annotation is presented, a short comparison with potato sequence data, and the tools available for the researchers to exploit this new resource are presented. Expand
Comparative sequence analysis of wheat and barley powdery mildew fungi reveals gene colinearity, dates divergence and indicates host-pathogen co-evolution.
Comparing the sequences of two loci in both cereal mildews to determine their divergence time and their relationship with the evolution of their hosts suggests that B. g. Expand
WebACT: an online genome comparison suite.
The process of using WebACT to prepare comparisons for visualization, and the selection of precomputed comparisons from the database are described. Expand
Simultaneous Suppression of Multiple Genes by Single Transgenes. Down-Regulation of Three Unrelated Lignin Biosynthetic Genes in Tobacco1
A novel method is tested by using single chimeric constructs incorporating partial sense sequences for multiple genes to target suppression of two or three lignin biosynthetic enzymes, indicating that chimeric silencing constructs offer great potential for the rapid and coordinate suppression of multiple genes on diverse biochemical pathways. Expand
Comparative analysis of the Saccharomyces cerevisiae and Caenorhabditis elegans protein interaction networks
It appears that meaningful inferences about the evolution of protein interaction networks require comparative analysis of reasonably closely related species and it is found that expression levels are better predictors of the evolutionary rate than a protein's connectivity. Expand