• Publications
  • Influence
Dysferlin stabilizes stress-induced Ca2+ signaling in the transverse tubule membrane
Significance Muscular dystrophies linked to the genetic absence or mutations of dysferlin are currently without a relevant therapy. Dysferlin is thought to mediate membrane repair in skeletal muscle,Expand
  • 84
  • 8
Lack of Correlation between Outcomes of Membrane Repair Assay and Correction of Dystrophic Changes in Experimental Therapeutic Strategy in Dysferlinopathy
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi Myopathy. The dysferlin protein has been implicated in sarcolemmal resealing, leading to the ideaExpand
  • 59
  • 4
  • PDF
The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
Obscurin is a large ( approximately 800-kDa), modular protein of striated muscle that concentrates around the M-bands and Z-disks of each sarcomere, where it is well positioned to sense contractileExpand
  • 42
  • 4
A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications
As of April 20, 2020, over time, the COVID‐19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, andExpand
  • 41
  • 4
Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from contraction-induced injuries.
We studied the response of dysferlin-null and control skeletal muscle to large- and small-strain injuries to the ankle dorsiflexors in mice. We measured contractile torque and counted fibersExpand
  • 56
  • 3
  • PDF
Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo
The protein, dysferlin, mediates sarcolemmal repair in vitro, implicating defective membrane repair in dysferlinopathies. To study the role of dysferlin in vivo, we assessed contractile function,Expand
  • 55
  • 2
Recovery of function in skeletal muscle following 2 different contraction-induced injuries.
OBJECTIVE To determine if the proliferation of myogenic cells is equally important to recovery of contractile function after 2 different types of contraction-induced muscle injuries. DESIGNExpand
  • 59
  • 2
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.
Mutations in the gene DYSF, which codes for the protein dysferlin, underlie Miyoshi myopathy and limb-girdle muscular dystrophy 2B in humans and produce a slowly progressing skeletal muscleExpand
  • 54
  • 2
Unmasking Potential Intracellular Roles For Dysferlin through Improved Immunolabeling Methods
Mutations in the DYSF gene that severely reduce the levels of the protein dysferlin are implicated in muscle-wasting syndromes known as dysferlinopathies. Although studies of its function in skeletalExpand
  • 23
  • 2
Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle
Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) dependent ROS generationExpand
  • 24
  • 1