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The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion (predominantly Cl−)-permeant GABAAExpand
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Cation–chloride co-transporters in neuronal communication, development and trauma
Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate currentExpand
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Molecular Characterization of a Putative K-Cl Cotransporter in Rat Brain
Using a combination of data base searching, polymerase chain reaction, and library screening, we have identified a putative K-Cl cotransporter isoform (KCC2) in rat brain that is specificallyExpand
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Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampalExpand
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Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades,Expand
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Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation.
  • J. A. Payne
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 November 1997
The neuronal K-Cl cotransporter isoform (KCC2) was functionally expressed in human embryonic kidney (HEK-293) cell lines. Two stably transfected HEK-293 cell lines were prepared: one expressing anExpand
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Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]oregulation.
  • J. A. Payne
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
  • 1 November 1997
The neuronal K-Cl cotransporter isoform (KCC2) was functionally expressed in human embryonic kidney (HEK-293) cell lines. Two stably transfected HEK-293 cell lines were prepared: one expressing anExpand
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Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2*
The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for hyperpolarizing membraneExpand
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Molecular Cloning and Functional Expression of the K-Cl Cotransporter from Rabbit, Rat, and Human
We report the cloning, sequence analysis, tissue distribution, and functional expression of the K-Cl cotransport protein, KCC1. KCC1 was identified by searching the human expressed sequence tag dataExpand
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Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter.
By mediating the coupled movement of Na, K, and Cl ions across the plasma membrane of most animal cells, the bumetanide-sensitive Na-K-Cl cotransporter (NKCC) plays a vital role in the regulation ofExpand
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