J. A. Marshall Graves

Publications77
h-index39
Citations4,128
Highly Influential Citations237
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Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes.
In therian mammals (placentals and marsupials), sex is determined by an XX female: XY male system, in which a gene (SRY) on the Y affects male determination. There is no equivalent in other amniotes,… Expand
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The promise of comparative genomics in mammals.
Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog… Expand
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The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.
Intronless genes can arise by germline retrotransposition of a cDNA originating as mRNA from an intron-containing source gene. Previously, we described several members of a family of intronless… Expand
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Temperature-dependent sex determination in the American alligator: expression of SF1, WT1 and DAX1 during gonadogenesis.
Sex determination in mammals and birds is chromosomal, while in many reptiles sex determination is temperature dependent. Morphological development of the gonads in these systems is conserved,… Expand
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Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein.
We report evidence from cDNA isolation and expression analysis as well as analyses of genome, expressed sequence tag (EST), cDNA and expression databases for a new gene named SPRN (shadow of prion… Expand
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Are homologies in vertebrate sex determination due to shared ancestry or to limited options?
The same candidate genes and the same autosomes are repeatedly used as sex chromosomes in vertebrates. Are these systems identical by descent, or are some genes or chromosomes intrinsically better at… Expand
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Sex from W to Z: evolution of vertebrate sex chromosomes and sex determining genes.
Sex determination in major vertebrate groups appears to be very variable, including systems of male heterogamety, female heterogamety and a variety of genetic and environmental sex determining… Expand
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Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis.
Recent findings of new genes in fish related to the prion protein (PrP) gene PRNP, including our recent report of SPRN coding for Shadoo (Sho) protein found also in mammals, raise issues of their… Expand
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The Evolution of Epigenetic Regulators CTCF and BORIS/CTCFL in Amniotes
CTCF is an essential, ubiquitously expressed DNA-binding protein responsible for insulator function, nuclear architecture, and transcriptional control within vertebrates. The gene CTCF was proposed… Expand
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The rise and fall of SRY.
Comparisons between species reveal when and how SRY, the testis-determining gene, evolved. SRY is younger than the Y chromosome, and so was probably not the original mammal sex-determining gene that… Expand
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