J. A. Kelly

Publications58
h-index20
Citations1,841
Highly Influential Citations34
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • J. Frère
  • 715 Publications • 22,650 Citations
  • J. Ghuysen
  • 341 Publications • 12,677 Citations
  • B. Joris
  • 316 Publications • 13,597 Citations
  • J. Knox
  • 136 Publications • 4,771 Citations
  • Publications
  • Influence
Crystallographic mapping of beta-lactams bound to a D-alanyl-D-alanine peptidase target enzyme.
Crystal structure of penicillin G acylase from the bro1 mutant strain of providencia rettgeri
TLDR
The structure of the Bro1 penicillin G acylase has been solved at 2.5 Å resolution by molecular replacement and a tightly bound calcium ion coordinated by one residue from the α‐sub unit and five residues from the β‐subunit has been identified.
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.
TLDR
Though the evolutionary distance may vary considerably, all these penicillin-interactive proteins and domains appear to be members of a single superfamily of active-site-serine enzymes distinct from the classical trypsin or subtilisin families.
Reconciliation of the X-ray and NMR structures of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG).
The thrombin-binding aptamer d(GGTTGGTGTGGTTGG) is one of a family of DNA oligonucleotides that were identified by in vitro selection to bind specifically and with high affinity to thrombin. Two…
On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target.
TLDR
Significant similarity found by x-ray crystallography in the spatial arrangement of the elements of secondary structure provides strong support for earlier hypotheses that beta-lactamases arose from penicillin-sensitive D-alanyl-D-alanine-peptidases involved in bacterial wall peptidoglycan metabolism.
X-ray crystallography of the binding of the bacterial cell wall trisaccharide NAM-NAG-NAM to lysozyme
TLDR
The X-ray structure of the non-hydrolysed13 trisaccharide NAM-NAG-NAM bound in subsites B, C, D is presented and it is shown that the interpretation of the 2.5-Å resolution difference map does not involve distortion of this residue in site D.
2.8-A Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with beta-lactams.
TLDR
The crystallographic structure of the penicillin-sensitive D-alanyl carboxypeptidase-transpeptidases from Streptomyces R61 has been solved to 2.8-A resolution and the binding at a common site of three types of beta-lactam has been observed in Fourier difference maps.
Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins
TLDR
A unified nomenclature of secondary structure elements is proposed for all the penicillin-recognizing enzymes.
Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".
...
1
2
3
4
5
...