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Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice.
- J. A. Grebb
- Chemistry, Medicine
- Life sciences
- 30 June 1986
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing amphetamine-induced behavioral stimulation in mice. Nifedipine, flunarizine and possibly PY 108-068 were effective in… Expand
Comments on article by Tran and associates, "Double-blind comparison of olanzapine versus risperidone in treatment of schizophrenia and other psychotic disorders".
Electrophysiologic abnormalities in patients with eating disorders.
Abstract The authors present a pattern of electrophysiologic abnormalities from a computer-analyzed, electroencephalogram (EEG) and averaged evoked potential (AEP) test battery used in the assessment… Expand
Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644
The calcium channel agonist BAY k 8644 was used to investigate the role of the calcium ion (Ca2+) in epileptogenesis. Intracerebroventricular administration of the compound induced murine seizures… Expand
Evidence for down-regulation of 3H-nitrendipine recognition sites in mouse brain after long-term treatment with nifedipine or verapamil
Mice were fed powdered food which contained nifedipine, verapamil or diltiazem for 28 days. Long lasting treatment with nifedipine (0.28 mg/g b.w./day) or verapamil (0.27 mg/g b.w./day), but not with… Expand
Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.
- C. Nordstedt, S. Gandy, +5 authors P. Greengard
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 October 1991
Alzheimer beta/A4 amyloid precursor protein (APP) has been suggested to play a central role in the pathogenesis of Alzheimer disease. We have measured the content of different species of APP… Expand
Differences between calcium channel inhibitors in their effects on phencyclidine-induced behavioral stimulation in mice
- J. A. Grebb, K. Ellsworth, W. Freed
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 October 1985
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing phencyclidine (PCP)-induced behavioral stimulation in mice. There were marked differences in the effects of CCI's both… Expand
A negative, double-blind, placebo-controlled, clinical trial of verapamil in chronic schizophrenia
Verapamil is a calcium channel inhibitor (CCI) of the papaverine subtype. This drug is in clinical use in the United States for the treatment of angina and cardiac arrhythmias. Verapamil has been… Expand
Chronic Treatment of Rats with SCH‐23390 or Raclopride Does Not Affect the Concentrations of DARPP‐32 or Its mRNA in Dopamine‐Innervated Brain Regions
- J. A. Grebb, J. Girault, M. Ehrlich, P. Greengard
- Biology, Medicine
- Journal of neurochemistry
- 1 July 1990
Abstract: DARPP‐32 (dopamine‐ and cyclic AMP‐regulated phosphoprotein, Mr= 32,000, as determined by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis) is a neuronal phosphoprotein that is… Expand
An analysis of synapsin II, a neuronal phosphoprotein, in postmortem brain tissue from alcoholic and neuropsychiatrically ill adults and medically ill children and young adults.
Synapsin II (formerly known as protein III) is a synaptic vesicle-associated neuronal phosphoprotein that may be involved in the regulation of neurotransmitter release. Synapsin II was studied in… Expand