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Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene
TLDR
Flies bearing fat facets gene mutations were used to show that a Ubp is cell type- and substrate-specific and a regulator of cell fate decisions in a multicellular organism.
The fat facets gene is required for Drosophila eye and embryo development.
TLDR
The faf gene is cloned, and it is shown that it encodes two similar large proteins that are unique with respect to other known proteins, including the determinant of posterior polarity, encoded by nanos.
Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease.
TLDR
Fat facets mutants and the cloned fat facets gene were used to show that, in order to limit the number of photoreceptors in a facet to eight, undifferentiated cells surrounding assembling facets send an inhibitory signal to extraneous cells within the facet preclusters.
Marbles mutants: uncoupling cell determination and nuclear migration in the developing Drosophila eye.
TLDR
In marbles mutant eyes, the sequence of cell specification that leads to the formation of facets occurs almost normally despite the failure of nuclear migration in many cells, revealing that during Drosophila eye development cell determination does not require nuclear migration.
A unique mutation in the Enhancer of split gene complex affects the fates of the mystery cells in the developing Drosophila eye.
TLDR
Results imply that one function of groucho is in a pathway whereby neuralization of the mystery cells is inhibited by other non-neural cells in the eye disc, and implies that induction by R2 or R5 is not absolutely necessary for R3/4 cell determination.