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Effects of Escherichia coli heat-stable enterotoxin STb on intestines of mice, rats, rabbits, and piglets
The concept that STb is a second heat-stable E. coli enterotoxin with properties and a mechanism of action unlike those of STa is supported.
Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds
It is suggested that disulfide compounds may alter the oxidation reduction state of a cell or act directly on the guanylate cyclase enzyme, whereas thiol compounds may inactivate ST itself by breaking its disulfides bridges, or it may alter guanylated cyclase activation by ST.
Effect of increasing thiolation of the polycytidylic acid strand of poly I: poly C on the α, β and γ interferon-inducing properties, antiviral and antiproliferative activities
Double-stranded RNAs induce interferons and cause the development of antiviral and antiproliferative activities. Antiviral activity is related to the production of interferons and other proteins that
Specific binding of [20-3H]12-deoxyphorbol 13-isobutyrate to phorbol ester receptor subclasses in mouse skin particulate preparations.
Comparison of binding by [3H]DPB with that by the typical phorbol ester [20-3H].phorbol 12,13-dibutyrate indicated that PDBU also bound to the sites recognized by DPB, with affinities of 0.7 and 10 nM, respectively.
In vitro characterization of a novel series of platelet-derived growth factor receptor tyrosine kinase inhibitors.
Winn 41662 is representative of a novel class of selective PDGF receptor tyrosine kinase inhibitors that inhibit PDGF-regulated secondary events in intact cells.
Potent inhibition of HIV-1 entry by (s4dU)35.
The studies identify (s(4)dU)(35) as a potential novel HIV entry inhibitor that may have utility as either a systemic antiretroviral or as a preventing agent for HIV transmission.
Immunoglobulin molecules are present in early‐generated neuronal populations in the rat cerebral cortex and retina
These studies suggest that subplate and other early‐generated neurons selectively take up Ig from serum, which may then either be degraded or lost from the central nervous system (CNS) during developmentally regulated cell death.
The carcinogenicity of steroid peroxides.
  • J. A. Dunn
  • Medicine
    British Journal of Cancer
  • 1 September 1965
WHILE investigating the effects of antihypertensive drugs on rats, the Oppenheimers incidentally demonstrated the carcinogenicity of plastics. The exact method whereby polymers initiate neoplastic