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Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen
- J. A. Deans, A. Knight, W. Jean, A. Waters, S. Cohen, G. Mitchell
- BiologyParasite immunology
- 1 September 1988
A minor Plasmodium knowlesi 66 kD antigen has been shown to be stable in distinct variants and strains of the parasite, and in the face of a specific immune response from the host, and Parasites were unable to produce novel molecule(s) to replace it functionally, even in the presence of specific immune pressure.
A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium.
Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi.
- J. A. Deans, T. Alderson, A. Thomas, G. Mitchell, E. Lennox, S. Cohen
- BiologyClinical and experimental immunology
- 1 August 1982
Inhibition was not associated with detectable damage to intracellular parasites, suggesting that the inhibitory monoclonal antibodies act by blocking the reinfection of red cells by newly released merozoites, suggesting potential interest as a vaccine against P. knowlesi malaria.
Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi
The antigenic composition of sequential erythrocytic stages of Plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum and differences in the relative amount of the stage-independent antigens have been demonstrated and quantified.
The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes.
Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen.
Immunology of malaria.
Cycle biologique du microorganisme, immunite acquise, vaccination contre le paludisme (stades exocrythocytaires, formes sanguines, formes sexuees)
Structural studies on a putative protective Plasmodium knowlesi merozoite antigen.
Stage-specific protein synthesis by asexual blood stage parasites of Plasmodium falciparum.