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Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen
Summary A minor Plasmodium knowlesi 66 kD antigen, which plays an essential role in merozoite invasion, has been shown to be stable in distinct variants and strains of the parasite, and in the faceExpand
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A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium.
The 66-kDa merozoite surface antigen (PK66) of Plasmodium knowlesi, a simian malaria, possesses vaccine-related properties that are thought to originate from a receptor-like role in parasite invasionExpand
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Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi.
A total of 28 double cloned monoclonal antibodies specific for Plasmodium knowlesi were raised by fusion of Y3 rat myeloma cells with spleen cells of A0 rats immunized with W1 variant isolatedExpand
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The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes.
Two rat monoclonal antibodies (both IgG2a isotype and having closely related specificities) and a pool of rhesus immune IgG, all of which inhibit Plasmodium knowlesi merozoite invasion of rhesusExpand
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Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi.
The antigenic composition of sequential erythrocytic stages of Plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum. Eleven majorExpand
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Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen.
A putative protective Plasmodium knowlesi antigen, recognized by two monoclonal antibodies which prevent invasion of erythrocytes by merozoites in vitro, is synthesised only by schizonts with 7 orExpand
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Immunology of malaria.
Cycle biologique du microorganisme, immunite acquise, vaccination contre le paludisme (stades exocrythocytaires, formes sanguines, formes sexuees)
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Structural studies on a putative protective Plasmodium knowlesi merozoite antigen.
  • J. A. Deans, W. Jean
  • Biology, Medicine
  • Molecular and biochemical parasitology
  • 1 November 1987
Two monoclonal antibodies, which prevent merozoites attaching to or invading erythrocytes, react with the same or closely apposed epitopes on a minor 66 kDa Plasmodium knowlesi antigen. The antigenExpand
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Stage-specific protein synthesis by asexual blood stage parasites of Plasmodium falciparum.
Highly synchronised cultures of cloned Plasmodium falciparum (clone T9-94) were metabolically radiolabelled with [35S]methionine during eight consecutive non-overlapping intervals, while parasitesExpand
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Stage-specific protein synthesis by asexual blood stage parasites of Plasmodium knowlesi.
P. knowlesi parasites with a maximum age distribution of 3 h were metabolically labelled with [35S]methionine during 9 sequential non-overlapping intervals, from young rings to mature segmentedExpand
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