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Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
TLDR
Together, these data suggest that CYP2J2-derived metabolites are cardioprotective after ischemia, and the mechanism for thisCardioprotection involves activation of mitoKATP and p42/p44 MAPK.
Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues
TLDR
The expression of CYPC9 and CYP2J2 in aorta and coronary artery is consistent with a physiological role for these enzymes in these tissues, and the results of immunoblotting and immunohistochemistry are consistent with this.
Cloning of CYP2J2 gene and identification of functional polymorphisms.
TLDR
It is concluded that allelic variants of the human CYP2J2 gene exist and that some of these variants result in a P450 protein that has reduced catalytic function.
Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation1
TLDR
Airway responsiveness in naive mice is influenced by gender, and that male mice have exaggerated airway inflammatory and functional responses to LPS compared with females, mediated, at least in part, by effects of androgens.
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia‐reperfusion injury in isolated mouse heart
TLDR
It is demonstrated that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R.
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms
TLDR
The effects of AA on KATP channels in freshly isolated cardiac myocytes from rats, wild‐type (WT) and transgenic mice overexpressing CYP2J2 cDNA, and mesenteric arterial smooth muscle cells from rats are examined.
Polymorphisms in human soluble epoxide hydrolase.
TLDR
The results suggest that at least six hsEH variants exist in the human population and that at at least four of these may influence h sEH-mediated metabolism of exogenous and endogenous epoxide substrates in vivo.
Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-α–deficient Mice
TLDR
Estrogen receptor-α knockout mice exhibit a variety of lung function abnormalities and have enhanced airway responsiveness to inhaled methacholine and serotonin under basa...
Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s.
TLDR
It is shown that P450s in the CYP1 and CYP2 gene families metabolize linoleic acid to linolesic acid monoepoxides and that the monoep oxides, as well as linoleoic acid, disrupt mitochondrial function without causing oxidative stress.
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
TLDR
The organization of the mouse Cyp2c locus is described, which contains 15 genes and four pseudogenes, all of which are located in a 5-megabase region on chromosome 19, and it is concluded that these new CYP2C enzymes are probably involved in AA and linoleic acid metabolism in mouse hepatic and extrahepatic tissues.
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