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Novel Signal Transduction Pathway Utilized by Extracellular HSP70
Recent studies have initiated a paradigm shift in the understanding of the function of heat shock proteins (HSP). It is now clear that HSP can and do exit mammalian cells, interact with cells of theExpand
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Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism*
Interleukins (IL) 1 and 6 are important cytokines that function via the activation, respectively, of the transcription factors NF-κB and STAT3. We have observed that a specific type of κB DNAExpand
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Modulation of Wnt5a Expression by Periodontopathic Bacteria
Wingless proteins, termed Wnt, are involved in embryonic development, blood cell differentiation, and tumorigenesis. In mammalian hematopoiesis, Wnt signaling is essential for stem-cell homeostasisExpand
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CONCISE REVIEW Biological: Interleukin 1 Signal Transduction— Current Concepts and Relevance to Periodontitis
This review examines a well-characterized factor, interleukin 1 (IL-1), that has recently received considerable attention. A level of understanding is emerging that goes beyond simple recognitionExpand
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TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src
Interleukin 1 (IL-1) has been implicated in the reorganization of the actin cytoskeleton. An expression vector encoding a PKB/Akt pleckstrin-homology domain fused to a fluorescent protein was used toExpand
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Distribution of cytokeratin markers in Barrett's specialized columnar epithelium.
BACKGROUND & AIMS The cell of origin for Barrett's epithelium is unknown. A multilayered epithelium within Barrett's epithelium has been noted recently. To investigate the hypothesis that thisExpand
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RANKL upregulation associated with periodontitis and Porphyromonas gingivalis.
BACKGROUND Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital rolesExpand
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Red bacterial complex is associated with the severity of chronic periodontitis in a Thai population.
BACKGROUND The distribution of periodontal pathogens differs in various geographic locations and racial/ethnic groups. This study investigated the microbiological features of chronic periodontitisExpand
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Role of macrophages in LPS-induced osteoblast and PDL cell apoptosis.
In periradicular lesions and periodontal disease, bacterial invasion leads to chronic inflammation resulting in disruption of the structural integrity of the periodontal ligament and progressiveExpand
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Induction of toll-like receptor expression by Porphyromonas gingivalis.
BACKGROUND Toll-like receptors (TLRs) play pivotal roles in host immune responses and have been suggested to be involved in the development of many infectious diseases. In this study, the mRNAExpand
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