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The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA‐binding protein and the syndrome results from… Expand
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are… Expand
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU‐rich elements
HeLa cytoplasmic extracts contain both 3′–5′ and 5′–3′ exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates… Expand
Pta1, a Component of Yeast CF II, Is Required for Both Cleavage and Poly(A) Addition of mRNA Precursor
- J. Zhao, M. Kessler, S. Helmling, J. .. O'connor, C. Moore
- Biology, Medicine
- Molecular and Cellular Biology
- 1 November 1999
ABSTRACT CF II, a factor required for cleavage of the 3′ ends of mRNA precursor in Saccharomyces cerevisiae, has been shown to contain four polypeptides. The three largest subunits, Cft1/Yhh1,… Expand
Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.
- C. Lutz, K. Murthy, N. Schek, J. .. O'connor, J. Manley, J. Alwine
- Biology, Medicine
- Genes & development
- 1 February 1996
We have previously shown that the U1 snRNP-A protein (U1A) interacts with elements in SV40 late polyadenylation signal and that this association increases polyadenylation efficiency. It was… Expand
A world catalogue of Chironomidae (Diptera), Part 1: Buchonomyiinae, Chilenomyiinae, Podonominae, Aphroteniinae, Tanypodinae, Usambaromyiinae, Diamesinae, Prodiamesinae and Telmatogetoninae.
In vivo pre-tRNA processing in Saccharomyces cerevisiae.
We have surveyed intron-containing RNAs of the yeast Saccharomyces cerevisiae by filter hybridization with pre-tRNA intron-specific oligonucleotide probes. We have classified various RNAs as… Expand
Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta.
- Fei Chen, M. Wang, J. .. O'connor, M. He, Tushar Tripathi, L. Harrison
- Journal of cellular biochemistry
Peroxisome proliferator-activated receptors (PPAR) are novel nuclear receptors and PPARgamma ligands have been shown to produce pro-apoptotic effects in many cancer cell types, including colon… Expand
Abdominal hernias complicating continuous ambulatory peritoneal dialysis.
Twenty-five percent of all CAPD patients reviewed in this study developed abdominal hernias. Eleven hernias (32.4%) occurred at the catheter insertion site, 17.6% were inguinal, 26.5% were epigastric… Expand
Additions and corrections to Part 1 of ‘A World Catalogue of Chironomidae (Diptera)’
An update of the more significant changes affecting Part 1 of ‘A World Catalogue of Chironomidae (Diptera)’ is provided. These concern new taxon names, new combinations and new synonymies that were… Expand