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In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication
TLDR
Results indicate that at least one of the 2,2-bis-hydroxymethyl derivatives may have potential for use in treating CMV and other herpesvirus infections in humans.
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Substrate specificity of ribosomal peptidyl transferase: 2'(3')-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site.
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Substrate Specificity of Ribosomal Peptidyl Transferase
The effect of the nature of the amino acid residue on the acceptor activity of substrates of ribosomal peptidyl transferase was investigated. We tested 2′(3′)-O-aminoacyladenosines containing the…
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(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
TLDR
Several Z-(hydroxymethyl)methylenecyclopropanes exhibited in vitro antiviral activity in micromolar or submicromolar range against human and murine cytomegalovirus (HCMV and MCMV), Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), varicella zoster virus (VZV), and hepatitis B virus (HBV).
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Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections
TLDR
Oral treatment with 45 or 15 mg of CPV/kg initiated 24 h after infection was highly effective in reducing replication to undetectable levels in both models and was generally more effective than ganciclovir.
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Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir
TLDR
PUL97 stereoselectively phosphorylates CPV to its (+)-monophosphate and helps explain its selective antiviral action.
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Substrate specificity of ribosomal peptidyl transferase. The effect of the nature of the amino acid side chain on the acceptor activity of 2'(3')-O-aminoacyladenosines.
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In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z-Methylenecyclopropane Nucleoside Analogues
TLDR
Two methylenecyclopropane nucleoside analogues with a phenylphosphoralaninate moiety exert potent and specific activities against human immunodeficiency virus type 1 strain LAI (HIV-1LAI) and HIV-2 in vitro.
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Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
TLDR
The second generation of methylenecyclopropane analogues of nucleosides 5a-5i and 6a-6i was synthesized and evaluated for antiviral activity, and the potency against Epstein-Barr virus (EBV) was assay-dependent.
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Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase.
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