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In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication
- E. Kern, Nicole L. Kushner, M. Prichard
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 March 2005
TLDR
Substrate specificity of ribosomal peptidyl transferase: 2'(3')-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site.
- I. Rychlík, J. Černá, S. Chládek, J. Žemlička, Z. Haladová
- Biology, ChemistryJournal of molecular biology
- 14 July 1969
Substrate Specificity of Ribosomal Peptidyl Transferase
- I. Rychlík, J. Černá, S. Chládek, P. Pulkrábek, J. Žemlička
- Chemistry, Biology
- 1 September 1970
The effect of the nature of the amino acid residue on the acceptor activity of substrates of ribosomal peptidyl transferase was investigated. We tested 2′(3′)-O-aminoacyladenosines containing the…
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
- Y. Qiu, M. Ksebati, J. Žemlička
- Chemistry, BiologyJournal of medicinal chemistry
- 1998
TLDR
Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections
- E. Kern, D. J. Bidanset, C. Hartline, Zhaohua Yan, J. Žemlička, D. Quenelle
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 December 2004
TLDR
Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir
- B. Gentry, J. Kamil, D. Coen, J. Žemlička, J. Drach
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 14 June 2010
TLDR
Substrate specificity of ribosomal peptidyl transferase. The effect of the nature of the amino acid side chain on the acceptor activity of 2'(3')-O-aminoacyladenosines.
- I. Rychlík, J. Černá, S. Chládek, P. Pulkrábek, J. Žemlička
- BiologyEuropean journal of biochemistry
- 1970
In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z-Methylenecyclopropane Nucleoside Analogues
- K. Yoshimura, Ron J. Feldman, H. Mitsuya
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 October 1999
TLDR
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
- Shaoman Zhou, J. Breitenbach, J. Žemlička
- Chemistry, BiologyJournal of medicinal chemistry
- 29 January 2004
TLDR
Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase.
- B. Gentry, Sara N. Gentry, Trachette L. Jackson, J. Žemlička, J. Drach
- Biology, ChemistryBiochemical pharmacology
- 2011
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