J. Ševčík

Publications161
h-index20
Citations1,529
Highly Influential Citations53
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Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint
Mutations in PPM1D/Wip1 phosphatase impair the DNA damage-induced checkpoint and may predispose cells to tumorigenesis.
Molecular phylogeny of the megadiverse insect infraorder Bibionomorpha sensu lato (Diptera)
The phylogeny of the insect infraorder Bibionomorpha (Diptera) is reconstructed based on the combined analysis of three nuclear (18S, 28S, CAD) and three mitochondrial (12S, 16S, COI) gene markers.…
DIPTERA ASSOCIATED WITH FUNGI IN CZECH AND SLOVAK REPUBLICS
K e y w o r d s: Diptera, insects, fungi, biology, ecology, taxonomy, Czech Republic, Slovakia, Europe. D v o u k ř í d l í v á z a n í n a h o u b y v Č e s k é a S l o v e n s k é r e p u b l i c e…
Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with mu-opioid receptors.
Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the development of fluoropyrimidine-related toxicity in patients with high-grade toxicity and patients with…
TLDR
The results indicate that genotyping of several DPYD variants may lead to stratification of patients with respect to the risk of serious hematological toxicity development during FPs treatment, and it is shown that C29R negatively correlated with overall gastrointestinal toxicity and M166V in women protected against overall hematology toxicity and neutropenia.
Hypoxic changes in rat locus coeruleus neurons in vitro.
TLDR
Early hypoxic depolarization and PHH are mostly due to the blockade and subsequent reactivation of the K(+)‐Na+ pump, respectively, and are caused by the opening of ATP‐sensitive K+ channels in response to the hypoxia‐induced decline of intracellular ATP.
Effects of potassium channel openers and their antagonists on rat locus coeruleus neurones
TLDR
Intracellular recordings suggest that KATP channels are present on the noradrenergic LC neurones, but are not coupled to α2‐adrenoceptors.
The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.
RNA regulation and cancer development.
Molecular phylogeny of fungus gnats (Diptera: Mycetophilidae) revisited: position of Manotinae, Metanepsiini, and other enigmatic taxa as inferred from multigene analysis
TLDR
The phylogeny of selected genera from four subfamilies of fungus gnats (Diptera: Mycetophilidae) is reconstructed based on the combined analysis of five mitochondrial (12S, 16S, COI, COII, cytB) and two nuclear (28S, ITS2) gene markers.
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