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Regulation of GSK3 isoforms by phosphatases PP1 and PP2A
Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate aExpand
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Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubuleExpand
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Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction.
Paired helical filaments isolated from the brains of patients with Alzheimer's disease are composed of a major protein component, the microtubule-associated protein termed tau, together with otherExpand
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Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Previous studies of the structure of core nanocrystals of ferritin (Ft) in the brains of patients with Alzheimer's disease (AD) have shown differences in the mineral compound in comparison withExpand
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Physicochemical characterization of the heat-stable microtubule-associated protein MAP2.
MAP2 purified without heat treatment was compared to MAP2 prepared with the usual boiling step. No significant differences were found by isoelectric focusing, peptide mapping, fluorescenceExpand
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Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics.
The microtubule cytoskeleton consists of a highly organized network of microtubule polymers bound to their accessory proteins: microtubule-associated proteins, molecular motors, andExpand
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Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragment.
Although a number of features distinguish the disease isoform of the prion protein (PrPSc) from its normal cellular counterpart (PrPC) in the transmissible spongiform encephalopathies (TSEs), theExpand
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Analysis of microtubule-associated protein tau glycation in paired helical filaments.
Alzheimer's disease is typified by the characteristic histopathological lesions of neurofibrillar plaques and tangles. The latter are composed of paired helical filaments (PHFs), the major componentsExpand
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Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.
Tubulin folding cofactors B (TBCB) and E (TBCE) are alpha-tubulin binding proteins that, together with Arl2 and cofactors D (TBCD), A (TBCA or p14) and C (TBCC), participate in tubulin biogenesis.Expand
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A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation
A neuroblastoma protein related to the brain microtubule-associated protein, MAP-1B, as determined by immunoprecipitation and coassembly with brain microtubules, becomes phosphorylated when N2A mouseExpand
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