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LIM homeobox domain 6 (LHX6) is a putative transcriptional regulator that controls the differentiation and development of neural and lymphoid cells. However, the function of LHX6 in cancer development remains largely unclear. Recently, we found that LHX6 is hypermethylated in lung cancer. In this study, we analysed its epigenetic regulation, biological(More)
The interaction of advanced glycation end products (AGE) and their specific cell-surface receptor (RAGE) has an important role in the pathogenesis of cardiovascular disease and diabetic complications. Two isoforms of C-truncated RAGE, soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE), may prevent activation of RAGE signaling by acting as decoys.(More)
Anurate oxidase (uricase, EC gene from Candida utilis AS2.117 was cloned by PCR amplification with primers derived from conserved regions of published uicase DNA sequence. The DNA sequence of cloned uricase gene was determined and a high homology compared to the reported gene was found. The cloned gene was inserted into Bam H I and Nde I sites of(More)
A cDNA encoding human O6-methylguanine-DNA methyltranferase (MGMT) was cloned from Hela S3 cells and the sequence is identical with the published data. The MGMT cDNA was inserted into the expression vector pET-21a and transformed into E. coli BL21 (DE3). A 24 kD protein was expressed after IPTG induction. Essays using lethal dose of alkylating agents(More)
A uricase producing strain, Candida utilis AS 2.117, was screened out and the uricase-forming conditions have been investigated. The results are obtained as follows: uric acid, xanthine and guanine were found to be effective inducers for enzyme formation. Corn steep liquor was essential for enzyme formation and cell growth. Sucrose, glucose, D-mannose and(More)
This study aimed to observe microvascular changes in the nasal mucosa of Sprague-Dawley (SD) rats with allergic rhinitis (AR) after persistent exposure to an allergen with fluticasone propionate (FP) treatment. Ninety healthy SD rats were randomly distributed into the control group (A, N = 30), the group with continued exposure to an allergen (B, N = 30),(More)
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