Learn More
To investigate the determinants of protein order and disorder, three primary and one derivative database of intrinsically disordered proteins were compiled. The segments in each primary database were characterized by one of the following: X-ray crystallography, nuclear magnetic resonance (NMR), or circular dichroism (CD). The derivative database was based(More)
OBJECTIVES To investigate the predictive validity and reliability of the STRATIFY falls risk assessment tool as applied to patients recovering from acute stroke. DESIGN Prospective cohort study. SETTING Six stroke rehabilitation units in the North of England. SUBJECTS All patients with a diagnosis of acute stroke admitted to the participating stroke(More)
BACKGROUND There are still substantial uncertainties over best practice in delirium care. The European Delirium Association (EDA) conducted a survey of its members and other interested parties on various aspects of delirium care. METHODS The invitation to participate in the online survey was distributed among the EDA membership. The survey covered(More)
—The multiwavelength optical networking (MONET) consortium has demonstrated national-scale optical networking in a multilocation testbed in New Jersey. The demonstration involves transparent optical connections over path lengths as long as 2290 km, through several network elements (NE's) controlled by two interoperating network control and management (NC&M)(More)
BACKGROUND Delirium is a common complication for older people in hospital. Evidence suggests that delirium incidence in hospital may be reduced by about a third through a multi-component intervention targeted at known modifiable risk factors. We describe the research design and conceptual framework underpinning it that informed the development of a novel(More)
BACKGROUND Frailty is common in older age, and is associated with important adverse health outcomes including increased risk of disability and admission to hospital or long-term care. Exercise interventions for frail older people have the potential to reduce the risk of these adverse outcomes by increasing muscle strength and improving mobility. (More)
BACKGROUND Case-mix represents the range of disease severity and baseline characteristics that may be the cause of variation in outcomes between individuals and populations. Adjustment for case-mix is therefore important to allow meaningful comparison of healthcare outcomes. The best available case-mix adjustment model for stroke (the Six Simple Variable(More)
BACKGROUND frailty is an especially problematic expression of population ageing. International guidelines recommend routine identification of frailty to provide evidence-based treatment, but currently available tools require additional resource. OBJECTIVES to develop and validate an electronic frailty index (eFI) using routinely available primary care(More)
The performance of a pair of multicrystal, high-resolution, bismuth germanate (BGO) block detectors for positron emission tomography (PET) has been investigated. Utilizing the detectors at a separation of 100 mm, the spatial resolutions and count rate response of the block have been measured. These measurements indicate maximum spatial resolutions of 3.6(More)
BACKGROUND AND OBJECTIVES delirium is a distressing but potentially preventable condition common in older people in long-term care. It is associated with increased morbidity, mortality, functional decline, hospitalization and significant healthcare costs. Multicomponent interventions, addressing delirium risk factors, have been shown to reduce delirium by(More)