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The purpose of this study was to evaluate the time-course effect of a 36-h treatment with ACTH (10 Ϫ8 M), transforming growth factor-␤1 (TGF␤1; 10 Ϫ10 M), angiotensin II (AngII; 10 Ϫ7 M), and insulin-like growth factor I (IGF-I; 10 Ϫ8 M) on the steroidogenic capacity of bovine adrenocortical cells (BAC) and on messenger RNA (mRNA) levels of ACTH receptor,(More)
A novel RIA was used to examine the release of agouti-related protein-like immunoreactivity (AGRP-LI) from perfused rat hypothalamic tissue slices and to characterize AGRP-LI in rat serum. A continuous low level basal AGRP-LI release was observed from hypothalami of rats fed ad libitum before the rats were killed. Basal AGRP-LI release was 3-fold greater in(More)
Agouti-related protein (AGRP) is an endogenous antagonist of melanocortin action that functions in the hypothalamic control of feeding behavior. Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are presently(More)
To explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was associated(More)
Studies concerning the identification of Secretogranin II (SgII) and its processed forms in human pituitary remain scarce since no anti-human SgII antisera has been available. In the present report, a specific hSgII antiserum was used in immunohistochemistry experiments to determine the distribution of SgII in normal anterior pituitaries and pituitary(More)
We examine the impact of credit default swaps (CDS) on debt covenant design. CDS provide creditors with a way to protect their credit exposures in lieu of active monitoring, and they increase creditors' bargaining power during debt renegotiations. Borrowers with CDS outstanding may in turn demand looser covenants to reduce the likelihood of costly(More)
We examine interactions between investment and financing decisions in a dynamic model where the firm may alter the mix of debt and equity financing and may exercise a growth option. The key feature of the model is that the growth option arrives randomly and can be lost due to competition or technological obsolescence. We find that the firm will typically(More)
The colour of red, purple, brown and white occurs in pericarp of rice. Here, the maize anthocyanin regulatory gene Lc under control of the promoter of the rice glutelin gene Gt1 was introduced in the white pericarp rice “Chao2-10” and purple pericarp rice “Qingjiaozidao”. The results demonstrated that some transgenic “Chao2-10” rice pericarps became brown,(More)
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