J. Y. Tu

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Aspiration efficiencies from nose and mouth inhalations are investigated at low and high inhalation rates by using the commercial Computational Fluid Dynamics (CFD) software CFX 11. A realistic human head with detailed facial features was constructed. Facial features were matched to represent the 50th percentile of a human male, aged between 20 and 65 years(More)
BACKGROUND This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a plaque. Numerical simulation has been used to answer how cap thickness and calcium distribution in lipids(More)
Anatomically precise geometric models of human airways and arterial vessels play a critical role in the analysis of air and blood flows in human bodies. The established geometric modelling methods become invalid when the model consists of bronchioles or small vessels. This paper presents a new method for reconstructing the entire airway tree and carotid(More)
Most of the cardiac abnormalities have an implication on hemodynamics and affect cardiovascular health. Diagnostic imaging modalities such as computed tomography and magnetic resonance imaging provide excellent anatomical information on myocardial structures, but fail to show the cardiac flow and detect heart defects in vivo condition. The computerized(More)
Numerical simulation is performed to demonstrate that hemodynamic factors are significant determinants for the development of a vascular pathology. Experimental measurements by particle image velocimetry are carried out to validate the credibility of the computational approach. We present a study for determining complex flow structures using the case of an(More)
A Grid based e-Research platform is being developed for providing a simulation-based virtual reality environment for clinical management and therapy treatment. The development of this platform involves cross-disciplinary experts aiming at combining the state-of-the-art Computational Fluid Dynamics (CFD) analysis tools into clinical management system. These(More)
Added-mass instability is known to be an important issue in the partitioned approach for fluid-structure interaction (FSI) solvers. Despite the implementation of the implicit approach, convergence of solution can be difficult to achieve. Relaxation may be applied to improve this implicitness of the partitioned algorithm, but this commonly leads to a(More)
A computational model was developed for studying the flow field and particle deposition in a human upper airway system, including: nasal cavity, nasopharynx, oropharynx, larynx and trachea. A series of coronal CT scan images of a 24 year old woman was used to construct the 3D model. The Lagrangian and Eulerian approaches were used, respectively, to find the(More)
Experimental images from particle/droplet image analyser (PDIA) and particle image velocimetry (PIV) imaging techniques of particle formation from a nasal spray device were taken to determine critical parameters for the study and design of effective nasal drug delivery devices. The critical parameters found were particle size, diameter of spray cone at a(More)
In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray(More)