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Background:This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.Methods:First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain(More)
BACKGROUND The primary management of adult soft tissue sarcomas (STS) is characterized by heterogeneity across centers. Several studies suggest that it is improved when coordinated by specialized sarcoma centers. PATIENTS AND METHODS This study, comparing STS patients of the Rhône-Alpes region treated within and outside the cancer network, retrospectively(More)
BACKGROUND The authors performed a specific analysis of the clinical significance of inguinal lymph nodes metastases in patients with anal canal carcinoma (ACC). METHODS A retrospective analysis was conducted of 270 patients who were treated in Lyon between 1980 and 1996 with radiotherapy with curative intent for ACC: No elective irradiation of clinically(More)
Two non-metallic vascular access port systems, the Multipurpose Access Port (MPAP) and Miniport, developed by CORDIS S.A., France, have been evaluated clinically in 78 cancer patients. During the investigational period covering a total experience of 369 treatment cycles and 1,370 infusion days, no cases of infection or septicemia were observed. Serious(More)
According to the criteria established by Cahan et al., we report 14 radiation induced sarcomas occurring in the treated volume after radiation therapy for adenocarcinoma of the breast. All these sarcomas were treated by wide surgical resection. In spite of a macroscopic free margin, only patients who underwent major amputation could hope to be cured. All(More)
Full thickness chest wall reconstruction must restore a leak-free and semirigid chest wall that allows good respiratory function. We present five consecutive cases of chest wall reconstruction with skeletal frame reconstruction by an osteomusculocutaneous latissimus dorsi flap. This flap allows transfer of the 11th and 12th ribs. The chest wall resection(More)
Short term preoperative irradiation of rectal cancer (30 Gy in 12 days) followed by a two-month rest before surgery has proven to be more efficient than most usual protocols of radiotherapy. In a series of 136 tumors T2, T3 or T4, tumor-free specimens and Duke'A lesions were found at surgery in 17% and 36% respectively. Surgeons took advantage of the tumor(More)
Following the wide excision of radiation necrosis, the treatment of these lesions has been transformed by the use of the myocutaneous flap technique. The most widely used, flaps are latissimus dorsi flaps for chest wall, subclavicular defects, pectoralis major flaps for defects of the neck and lower part of the face, fascia lata flaps to treat lesions of(More)
One hundred and thirty-nine chambers for injection or infusion of cytotoxic drugs were implanted in 9 French anticancer centres, because of inadequate peripheral veins. A strict surgical procedure and a good training of the nursing staff are necessary to avoid complications (27.7%, including 7% obstructions). Complications associated with the material are(More)
In a series of 181 patients with breast cancer treated by mastectomy with axillary lymph node dissection, the authors developed and used an improved topographic technique, which they call the "Grid Method", which maps out the extent of a given cance of the breast. Three types of tumor spread are defined: Type 1, limited (L)(31%); Type 2, multifocal(More)