J. X. Brunner

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To evaluate a least squares fitting technique for the purpose of measuring total respiratory compliance (Crs) and resistance (Rrs) in patients submitted to partial ventilatory support, without the need for esophageal pressure measurement. Prospective, randomized study. A general ICU of a University Hospital. 11 patients in acute respiratory failure,(More)
Closed loop control of ventilation is traditionally based on end-tidal or mean expired CO/sub 2/. The controlled variables are the respiratory rate RR and the tidal volume V/sub T/. Neither patient size or lung mechanics were considered in previous approaches. Also the modes were not suitable for spontaneously breathing subjects. This report presents a new(More)
OBJECTIVE Before a patient can be connected to a mechanical ventilator, the controls of the apparatus need to be set up appropriately. Today, this is done by the intensive care professional. With the advent of closed loop controlled mechanical ventilation, methods will be needed to select appropriate start up settings automatically. The objective of our(More)
To test a method that allows automatic set-up of the ventilator controls at the onset of ventilation. Prospective randomized crossover study. ICUs in one adult and one children's hospital in Switzerland. Thirty intubated stable, critically ill patients (20 adults and 10 children). The patients were ventilated during two 20-min periods using a modified(More)
To describe structure and function of a PC based blood gas interpretation program (ABG-consultant) developed for nurses and physicians, and to test educational impact and user acceptance. Prospective, blinded study Interdisciplinary ICU of a county hospital in Switzerland Nurses specialized in intensive care Exposure to the ABG-consultant program A first(More)
Adaptive Support Ventilation is a novel ventilation mode, a closed-loop control mode that may switch automatically from a PCV-like behaviour to an SIMV-like or PSV-like behaviour, according to the patient status. The operating principles are based on pressure-controlled SIMV with pressure levels and SIMV rate automatically adjusted according to measured(More)
Objective: We prospectively assessed the impact of bronchoalveolar lavage (BAL) on respiratory mechanics in critically ill, mechanically ventilated patients. Study design: Mechanically ventilated patients underwent BAL of one lung segment using 5 × 20 ml of sterile, physiologic saline with a temperature of 25–28 °C. The fractional inspired oxygen was(More)
OBJECTIVE Airway occlusion pressure at 0.1 sec (P0.1) is an index of respiratory center output. During pressure-support ventilation, P0.1 correlates with the mechanical output of the inspiratory muscles and has an inverse relationship with the amount of pressure-support ventilation. Based on these observations, we designed a closed-loop control which, by(More)
Measurement of respiratory gas composition by a mass spectrometer lags behind the measurement of gas flow. To obtain specific gas volumes (e.g., the N2 volume) by multiplication and integration of concentration and flow, one has to synchronize flow and concentration signals using the delay time (TD) of the gas analyzer. During the N2 washout, however, gas(More)