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Sex differences and gonadal hormone influences are well known for diverse aspects of forebrain amine and indolamine neurotransmitter systems, the cognitive and affective functions they govern and their malfunction in mental illness. This study explored whether hormone regulation/dysregulation of these systems could be related to gonadal steroid effects on(More)
BACKGROUND Selumetinib (AZD6244, ARRY-142886)+docetaxel increases median overall survival (OS) and significantly improves progression-free survival (PFS) and objective response rate (ORR) compared with docetaxel alone in patients with KRAS mutant, stage IIIB/IV non-small-cell lung cancer (NSCLC; NCT00890825). METHODS Retrospective analysis of OS, PFS, ORR(More)
BACKGROUND Thyroid neoplasia is common in dogs, but there are few reports of dogs with ectopic, sublingual thyroid tumors. OBJECTIVES To describe clinical features and outcomes of dogs with ectopic, sublingual thyroid neoplasia. ANIMALS Five hundred and forty-four dogs with thyroid neoplasia. METHODS This retrospective study reviewed the medical(More)
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