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We have cloned the junction region of the previously characterized Yunnanese (Aγδβ)0-thalassemia deletion and the normal DNA region surrounding its 3′ breakpoint. The sequence of 1138 bp of the 3′-flanking region and 555 bp of the normal region surrounding the 3′ breakpoint was determined. The 5′ breakpoint of the deletion is positioned between 116 and 117(More)
Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer’s disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C(−889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A(More)
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