J. W. J. M. Rutten

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INTRODUCTION CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation in the small- to medium sized arterioles. The accumulation is systemic but most pronounced in the brain vasculature where(More)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, or CADASIL, is a hereditary cerebral small vessel disease caused by characteristic cysteine altering missense mutations in the NOTCH3 gene. NOTCH3 mutations in CADASIL result in an uneven number of cysteine residues in one of the 34 epidermal growth factor(More)
In this paper we propose a divide and conquer strategy for the calculation of hazard free prime implicants. It is capable of calculating all hazard free prime implicants but it can be restricted to calculate only those primes that can possibly contribute to a solution. We show that this significantly reduces the number of generated primes, and thus reduces(More)
In this paper we introduce the first divide and conquer algorithm that is capable of exact hazard-free logic minimization in a constructive way. We compare our algorithm with the method of Dill/Nowick, which was the only known method for exact hazard-free minimization. We show that our algorithm is much faster than the method proposed by Dill/Nowick by(More)
BACKGROUND Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners.(More)
OBJECTIVE To determine the frequency of distinctive EGFr cysteine altering NOTCH3 mutations in the 60,706 exomes of the exome aggregation consortium (ExAC) database. METHODS ExAC was queried for mutations distinctive for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), namely mutations leading to a(More)
Disulfide bonds are an important class of protein post-translational modifications, yet this structurally crucial modification type is commonly overlooked in mass spectrometry (MS)-based proteomics approaches. Recently, the benefits of online electrochemistry-assisted reduction of protein S-S bonds prior to MS analysis were exemplified by successful(More)
| In this paper, we examine two recently developed design styles aimed at the implementation of low-power circuits. These design styles are the use of clock-gating in the synthesis of synchronous circuits and the use of burst-mode machines in the synthesis of asynchronous circuits. Our evaluation consists of the design of a well-known circuit, namely a(More)
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