J W Damowski

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This phase I trial evaluated a high-dose, short-term infusion of zidovudine (AZT) following oral leucovorin (LV) and bolus 5-fluorouracil (FUra). Thirteen patients with metastatic cancer received 30 cycles of therapy. Plasma monitoring demonstrated a dose-dependent increase in peak plasma levels of AZT through the range of dose levels, from 104.3 +/- 8.7(More)
Stage II human trials have indicated that the combination of 3′-azido-3′-deoxythymidine (AZT) with 5-fluorouracil and leucovorin has improved efficacy in the adjuvant chemotherapy of colorectal cancer. The development of resistance to AZT has been well documented in viral metabolism, but has not been fully described in human cells. This renders the drug(More)
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