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The three component Grieco condensation of indazoles, aliphatic/aromatic aldehydes, and electron rich olefins in the presence of GdCl3 resulted in a novel pyrimidine fused indazoles in single pot under mild conditions. Representative examples were screened for in vitro anti-cancer activity and some of the compounds exhibited promising cytotoxic activity(More)
BACKGROUND AND THE PURPOSE OF THE STUDY Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its selectivity and specificity on the smooth vascular cells. The pharmacokinetic parameters make LRDP a suitable candidate for transdermal delivery. The purpose of the study was to select a suitable formulation for the development(More)
Sub-lethal studies of chlorpyrifos, O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate on mosquito fish, Gambusia affinis were carried out in vivo, for 20 days to assess the locomotor behavior in relation to bioaccumulation and interaction with a targeted enzyme, acetylcholinesterase (AChE, EC: 3.1.1.7). Fish exposed to sub-lethal concentration of(More)
Locomotor behavior is commonly affected by contaminants, and the pattern of fish swimming is a highly organized species-specific response. In the current study, we examined the locomotor behavioral response of the mosquitofish, Gambusia affinis, which was exposed to a sublethal concentration (LC(5), 20 microg/L) of mercuric chloride (HgCl2) for 28 days and(More)
A new series of fluoro 1,2,3-triazole tagged amino bis (benzothiazole) derivatives 8, 9 were prepared starting from 2-amino benzothiazole in four steps via amination, cyclization, alkylation followed by reaction with various azides under sharpless conditions through click chemistry approach. All newly synthesized compounds were screened for their(More)
Living in an environment that has been altered considerably by anthropogenic activities, fish are often exposed to a multitude of stressors including heavy metals. Copper ions are quite toxic to fish when concentrations are increased in environmental exposures often resulting in physiological, histological, biochemical and enzymatic alterations in fish,(More)
This paper proposes a new bus coding scheme for reducing the crosstalk in System on chip(soc). As circuit geometries become smaller, wire interconnections become closer together and taller, thus increasing the cross-coupling capacitance between nets. At the same time, parasitic capacitance to the substrate becomes less as interconnections become narrower,(More)
An endophytic fungal strain isolated from the leaves of Gymnema sylvestre was identified as Pestalotiopsis microspora VJ1/VS1 based on nucleotide sequencing of internal transcribed spacer region (ITS 1-5.8S-ITS 2) of 18S rRNA gene (NCBI accession number KX213894). In this study, an efficient and ecofriendly approach has been reported for the synthesis of(More)
BACKGROUND Polio eradication needs a new routine immunisation schedule--three or four doses of bivalent type 1 and type 3 oral poliovirus vaccine (bOPV) and one dose of inactivated poliovirus vaccine (IPV), but no immunogenicity data are available for this schedule. We aimed to assess immunogenicity of this vaccine schedule. METHODS We did an open-label,(More)
Recently, reducing crosstalk noise delay is an important issue in VLSI design. As circuit geometries become smaller, wire interconnections become closer together and taller, thus increasing the cross-coupling capacitance between nets. At the same time, parasitic capacitance to the substrate becomes less as interconnections become narrower, and cell delays(More)
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