J.V. Sweedler

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Nanofluidics presents growing and exciting opportunities for conducting fundamental studies for processes and systems that govern molecular-scale operations in science and engineering. In addition, nanofluidics provides a rapidly growing platform for developing new systems and technologies for an ever-growing list of applications. This review presents a(More)
A multiple layer biochemical micro-analytical system has been developed that allows several functions to be conducted on mass limited (attomolar) samples of analytes that are in high backgrounds of constituent molecules. The functions are enabled by nanofluidic interconnects that join separate microfluidic channels, which carry various buffer solutions,(More)
Bioinformatic predictions of neuropeptides resulting from enzymatic cleavages of precursors enable a range of follow-up studies that are aided by accurate predictions. A comparative study of the performance of complementary cleavage prediction models has been undertaken. Binary logistic and artificial neural network (ANN) models were created using various(More)
Microfluidic devices allow manipulation of reagents and fluids in a semi-automated fashion, ideal for performing multiple measurements or conditioning various reagents. Here, an enzyme assay has been performed in a multilayer poly(methyl methacrylate)-based microfluidic device, where the layers are fluidically connected via a nanocapillary array membrane(More)
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