J. Timothy Field

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The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significant cell death in a wide range of human tumor cell lines,(More)
The Pringle is a 64 processor MIMD computer with a 64 M (8 bit) instructions per second execution rate. (Copies are running at Purdue and Washington.) The Pringle runs programs written for the Configurable, Highly Parallel (CHiP) Computer. That is, the Pringle executes the 64 separate instruction streams as well as the interconnection (phase) stream that(More)
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