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Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals. This occurs through both unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay of(More)
One hundred and twenty patients with bronchogenic carcinoma were prospectively studied by both computed tomography (CT) and magnetic resonance imaging (MRI) during the 2 weeks preceding thoracotomy or mediastinoscopy. MRI scans included contiguous axial and coronal slices. Results of CT and MRI studies were compared with the surgical and pathological(More)
Complete study of the sella turcica requires multidirectional tomography. The authors have studied 200 radiographs of normal adults and noted the percentage of variants of each anatomical feature on both standard radiographs and tomograms. The greatest drawback of the standard radiograph is the difficulty in objectively evaluating the effect of(More)
A recombinant plasmid containing human interleukin 2 (IL2) cDNA was identified in a cDNA library constructed from mRNA derived from PHA-TPA induced splenocytes. Using this cDNA as a hybridization probe, a DNA fragment containing the IL2 gene was isolated from a collection of hybrid phages derived from human genomic DNA. A unique reading frame was identified(More)
Retroperitoneal teratomas are rare in adults; they are malignant in 25.8% of cases. The authors report two benign cases in which radiologic examination was essential in establishing the diagnosis. Irregular calcifications, which are visible in 61.5% of reported cases, cannot be considered a sign of benignity, since 12.5% of calcified tumors were malignant.(More)
OBJECTIVE To estimate thyroid doses and cancer risk for paediatric patients undergoing neck computed tomography (CT). METHODS We used average CTDI(vol) (mGy) values from 75 paediatric neck CT examinations to estimate thyroid dose in a mathematical anthropomorphic phantom (ImPACT Patient CT Dosimetry Calculator). Patient dose was estimated by modelling the(More)