J. Takeuchi

M. Sobue7
T. Morimura4
7M. Sobue
4T. Morimura
3T. Fukatsu
3T. Nagasaka
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— We analyze the relationship between a Minimum Description Length (MDL) estimator (posterior mode) and a Bayes estimator for exponential families. We show the following results concerning these estimators: a) Both the Bayes estimator with Jeffreys prior and the MDL estimator with the uniform prior with respect to the expectation parameter are nearly(More)
The overexpression of the multidrug resistance (mdr1) gene and its product, P-glycoprotein (P-gp), is thought to limit the successful chemotherapy of human tumours. The mechanism by which mdr1 gene and P-gp are overexpressed in human tumours, however, is not yet clear. In this report, we show that the mdm2 (murine double minute 2) gene induced the(More)
Proteoglycans (PGs) were localised immunohistochemically in 52 salivary gland tumours including pleomorphic adenoma, adenoid cystic carcinoma, acinic cell carcinoma, oncocytoma, mucoepidermoid carcinoma, clear cell tumour and Warthin tumour, using antibodies raised against large PG, small PG, chondroitin 4-sulphate PG, chondroitin 6-sulphate PG, heparan(More)
Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and delta Di-6S binding to core protein via a(More)
The glycosaminoglycan (GAG) content of stomach carcinoma tissue was compared with that of non-neoplastic mucosa. GAG synthesis was also studied, by an analysis of 35S-labelled material after incubation of tissue segments in medium containing 35SO4. No significant difference was found between the amount of GAG and its components in the medullary carcinoma(More)
We attempted to determine whether calcium channel blockers (CCBs) enhance the anti-tumour activity of cis-diamminedichloroplatinum (cisplatin) against both cisplatin-sensitive human glioblastoma U87 MG cells and cisplatin-resistant U87-MG-CR cells, the latter of which we developed for resistance to cisplatin. Nifedipine, a dihydropyridine class CCB,(More)
Recent studies have shown that the use of cytokines such as granulocyte colony-stimulating factor (G-CSF) to ameliorate chemotherapy-induced myelosuppression may enhance the viability of tumour cells with functional receptors for these cytokines. In this study, therefore, we used murine bone marrow (BM) cells in an in vitro model in an attempt to determine(More)
IN WELL-DIFFERENTIATED liposarcoma there are commonly observed mucinous areas that have merged with a vascular tissue, mainly composed of small and large lipocytes of varying degrees of maturity. It was demonstrated by biochemical and histochemical investigations that the lipo-sarcoma tissue contained glycosamino-glyeans (GAG) consisting mainly of(More)
The mechanism by which tumour necrosis factor (TNF)-alpha increases the susceptibility of U87-MG human glioblastoma cells to lysis by natural killer (NK) cells was studied. Treatment with TNF-alpha (100 units ml-1) for 48 h enhanced the susceptibility of tumour cells to lysis by NK cells. Increased susceptibility to lysis was associated with enhanced(More)
The basement membrane components produced by proliferating epithelial cells may play a role in maintaining a relationship between epithelial cells and interstitial mesenchymal cells in tumour or embryonic tissues as they grow. The basement membrane contains several common components including collagen, glycoprotein and proteoglycan. Type IV collagen is a(More)