J T Hwang | Semantic Scholar

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Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen…

J T Hwang, Marc M Greenberg, Tanja Fuchs, Kent S Gates
Biochemistry
1999

The compound 3-amino-1,2,4-benzotriazine 1,4-dioxide (1, tirapazamine; also known as SR4233, WIN 59075, and tirazone) is a clinically promising anticancer agent that selectively kills the oxygen-poor… (More)

Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA.

Yong-jie Xu, Michael S Demott, J T Hwang, Marc M Greenberg, Bruce Demple
DNA repair
2003

Oxidative damage to DNA includes diverse lesions in the sugar-phosphate backbone. The chemical "nuclease" bis(1,10-phenanthroline)copper complex [(OP)(2)Cu] is believed to generate a mixture of… (More)

Photosensitization of guanine-specific DNA damage by a cyano-substituted quinoxaline di-N-oxide.

Tanja Fuchs, Kent S Gates, J T Hwang, Marc M Greenberg
Chemical research in toxicology
1999

The cyano-substituted quinoxaline di-N-oxide (2) is a potential antitumor agent, which selectively kills hypoxic cells. While investigating this drug's potential ability to act as a surrogate for… (More)