J. T. Beranek

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Human pleural malignant mesothelioma was successfully transplanted into nude mice from 2 of 3 patients. The tumor implants of the first generation grew in 6 of 20 mice (30%), with a take of implants of 17 of 32 (53%). Overall, tumors grew from 52 of 80 mice (65%) in a total of 169 of 266 implants (64%) during the first four generations. The mean delay(More)
Sir Rubens et al. (1988) think that prednisolone exercises anti-oestrogenic and direct cytostatic effects in the therapy of breast cancer. I believe that the third hypothesis should be also mentioned: in vivo corticosteroid anti-angiogenesis. Ever since Sakamoto & Tanaka (1988) documented the in vitro anti-angiogenic effect of corticosteroids alone and its(More)
Data are presented which show that the increased binding of morphine by sera from rabbits which had been treated with morphine in an appropriate manner is mediated by immunoglobulins and is specific. These observations, together with findings reported in the preceding paper, suggest that morphine or one of its derivatives can evoke specific immune(More)
With a research interest in angiogenesis and antiangiogenesis (Beranek, 1988), I have read the article by Yudoh et al (2001) concerning microvessel density (MVD) and the concentration of vascular endothelial growth factor (VEGF) in soft tissue sarcomas. The authors have found that no significant correlation exists between MVD and the concentration of VEGF(More)
The effects of temperature on the anthracycline antibiotics-induced cell kill of DND-1A human malignant melanoma (MM) and DND-39A Burkitt's lymphoma (BL) cell lines were studied by means of a clonogenic assay. The two cell lines differed in sensitivity when exposed to heat: The MM cells were unaffected by hyperthermia (42 degrees C), whereas BL cells were(More)
The establishment of permanent acute lymphocytic leukemia (ALL) lines of different phenotypes permits the study of their sensitivity to chemotherapeutic agents. The sensitivity of four ALL cell lines, two T-cell lines and one each of B- and non-T/non-B cell lines, to eight chemotherapeutic agents was studied by means of clonogenic assay. Response data were(More)