J. Sunil Rao

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This assessment of the current status of science and technology in India focuses on developments in the areas of agriculture, energy, medicine, space, basic sciences, and engineering sciences. India has benefited in many fields from international collaboration during the last 30 years, but the country's leaders have also placed particularly strong emphasis(More)
In gene selection for cancer classification using microarray data, we define an eigenvalue-ratio statistic to measure a gene's contribution to the joint discriminability when this gene is included into a set of genes. Based on this eigenvalue-ratio statistic, we define a novel hypothesis testing for gene statistical redundancy and propose two gene selection(More)
Crooked tail (Cd) mice bear a gain-of-function mutation in Lrp6, a co-receptor for canonical WNT signaling, and are a model of neural tube defects (NTDs), preventable with dietary folic acid (FA) supplementation. Whether the FA response reflects a direct influence of FA on LRP6 function was tested with prenatal supplementation in LRP6-deficient embryos. The(More)
O ver the last 10 to 20 years, the search for mechanisms responsible for cardiac remodeling during cardiac hypertrophy and failure has been hampered by the experimental tools available (primarily Western blot analysis and polymerase chain reaction). This is because these approaches only permit measurement of the expression levels of a few preselected genes(More)
Background: DNA microarrays open up a new horizon for studying the genetic determinants of disease. The high throughput nature of these arrays creates an enormous wealth of information, but also poses a challenge to data analysis. Inferential problems become even more pronounced as experimental designs used to collect data become more complex. An important(More)
Like all articles in BMC journals, this peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: DNA microarrays(More)
We present a visual tablet for exploring the nature of a bagged decision tree (Breiman [1996]). Aggregating classifiers over bootstrap datasets (bagging) can result in greatly improved prediction accuracy. Bagging is motivated as a variance reduction technique, but it is considered a black box with respect to interpretation. Current research seekine: to(More)
This paper summarizes contributions to group 12 of the 15th Genetic Analysis Workshop. The papers in this group focused on multivariate methods and applications for the analysis of molecular data including genotypic data as well as gene expression microarray measurements and clinical phenotypes. A range of multivariate techniques have been employed to(More)
Standard genetic mapping techniques scan chromosomal segments for location of genetic linkage and association signals. The majority of these methods consider only correlations at single markers and/or phenotypes with explicit detailing of the genetic structure. These methods tend to be limited by their inability to consider the effect of large numbers of(More)