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Body temperature, urine output, osmotic and free water clearances, plasma osmolality, sodium and potassium concentrations, blood lactate level, osmotic thirst and central blood volume were measured in dogs exposed to cold (+1 to -8 degrees C) for 1-3 hours and compared to those obtained under control conditions at ambient temperatures (18-20 degrees C). In(More)
Seven dogs were chronically implanted with 30 electrodes directed at various structures of the basal forebrain. Osmotic thirst threshold (expressed as an increase in plasma osmolality and a decrease in cellular water content caused by an intravenous infusion of 5% NaCl, necessary to induce drinking) was measured during electric stimulation of the basal(More)
To determine whether centrally released vasopressin influences thirst, observations of osmotic thirst threshold, osmotic load excretion and postloading restitution of plasma osmolality were made in dogs in control experiments and during infusion of AVP antagonists into the third ventricle. Significant elevation of osmotic thirst threshold was elicited by(More)
Reactivity of the thirst mechanism to osmotic stimuli was measured in conscious dogs chronically implanted with electrodes in the basal forebrain. It was found that the thirst threshold to the osmotic stimulus increases markedly during electrical stimulation of the preoptic area, septum, nucleus accumbens septi, and to smaller degree during stimulation of(More)
The effect of electrical brain stimulation (ESB; 50 Hz, 50-150 microA sine wave, 5 s on/5 s off) on osmotic thirst was examined in 10 conscious dogs chronically implanted with electrodes aimed at the anteromedial part of the basal forebrain. Suppression of osmotic thirst (SOT) was observed during stimulation through 18 of 41 electrodes located in the(More)
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