J. Shakhanbeh

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Forty-three high threshold mechanoreceptors (HTMs) with myelinated fibres were characterized in hairy and glabrous skin of the hind limb of the rat. Mechanical thresholds and conduction velocities were similar in both skin areas. The behaviour of 15 hairy and 14 glabrous skin HTMs were studied in response to repeated heating to 55-60 degrees C. Responses to(More)
The long-term effects of applying capsaicin briefly to a cutaneous nerve in the rabbit have been assessed 10 days after treatment. No changes in C-fibre numbers were seen in treated saphenous nerves and the average ratio of C-fibres to A-fibres was close to 7 in both control and treated nerves. However, the substance P content of the skin innervated by the(More)
A flare-like spread of vasodilatation can be demonstrated in the limb skin of the anaesthetised rabbit using laser doppler flowmetry. Spread of dilatation from a small mechanical injury (nicking the skin) extends 5–10 mm. The size and time course of the dilatation are as expected from the low frequency C-nociceptor firing that occurs in response to similar(More)
The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory organ weights were significantly reduced(More)
The effect of morphine was examined under identical conditions on (a) antidromic vasodilatation, an 'efferent' function of C-nociceptors in the skin, and (b) afferent responses to heat and pressure of C-polymodal nociceptors. Morphine caused a large, naloxone-reversible, fall in peak antidromic vasodilatation (ADV). However it caused no significant change(More)
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