J. Schoelmerich

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Die Entwicklung einer sekundär sklerosierenden Cholangitis (SSC) aufgrund einer chronischen Gallengangsobstruktion oder als Komplikation nach Lebertransplantation ist schon seit längerem beschrieben. Eine sklerosierende Cholangitis als Komplikation bei schwerkranken Intensivpatienten ist eine noch wenig bekannte neue Form der SSC, wobei die Zahl der neu(More)
AIM To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial(More)
INTRODUCTION Rheumatoid arthritis synovial fibroblasts (RASF) are key players in synovial pathophysiology and are therefore examined extensively in various experimental approaches. We evaluated, whether passaging during culture and freezing has effects on gene expression and cell proliferation. METHODS RASF were passaged for up to 8 passages. RNA was(More)
AIM To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic(More)
Das Auftreten von Aszites ist ein unspezifisches klinisches Symptom, das in Abhängigkeit von der zugrundeliegenden Ursache unterschiedlichste therapeutische und/oder prognostische Konsequenzen haben kann. Erläutert werden die pathophysiologischen Grundregeln der Aszitesformation und die sich daraus ableitenden Parameter, die in der Differenzialdiagnose(More)
The coinfusion of tauroursodeoxycholate (TUDC) prevents taurolithocholate (TLC) -induced cholestasis. 23-Methyl-ursodeoxycholate (MUDC) is a side-chain derivative of ursodeoxycholate (UDC). If conjugation with taurine is important for the protective effect of UDC, then MUDC may not be as able as TUDC to prevent TLC-induced cholestasis since it is poorly(More)
Drug treatment does not play a significant role either in the maintenance of remission induced by drugs or surgery in Crohn's disease. Considering the data available, it is reasonable that after resection of involved bowel segments an attempt is made to avoid relapses using a suitable 5-ASA preparation. This remains an individual decision following(More)
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