J S Wilkinson

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We present measurements of biomolecular binding reactions, using a new type of integrated-optical biosensor based on a planar directional coupler structure. The device is fabricated by Ag(+) - Na(+) ion exchange in glass, and definition of the sensing region is achieved by use of transparent fluoropolymer isolation layers formed by thermal evaporation. The(More)
  • Sudeep Mandal, David Erickson, S D Erickson, A Mandal, B Yang, Cordovez +70 others
  • 2008
In this paper we introduce Nanoscale Optofluidic Sensor Arrays (NOSAs), which are an optofluidic architecture for performing highly parallel, label free detection of biomolecular interactions in aqueous environments. The architecture is based on the use of arrays of 1D photonic crystal resonators which are evanescently coupled to a single bus waveguide.(More)
We present a micropatterning method for the automatic transfer and arbitrary positioning of computer-generated three-dimensional structures within a substrate. The Gerchberg-Saxton algorithm and an electrically addressed spatial light modulator (SLM) are used to create and display phase holograms, respectively. A holographic approach to light manipulation(More)
The development of a multichannel spectrometer based on single mode planar integrated optical waveguide and capable of measuring broad-band visible absorbance spectra of a weakly absorbing molecular film at a solid-liquid interface is reported. The system was successfully tested by measuring spectra, over a 100 nm bandwidth, of a hydrated film of cytochrome(More)
In this work, we demonstrate improved molecular detection sensitivity for silicon slab photonic crystal cavities by introducing multiple-hole defects (MHDs), which increase the surface area available for label-free detection without degrading the quality factor. Compared to photonic crystals with L3 defects, adding MHDs into photonic crystal cavities(More)
We demonstrate monolithic 160-µm-diameter rare-earth-doped microring lasers using silicon-compatible methods. Pump light injection and laser output coupling are achieved via an integrated silicon nitride waveguide. We measure internal quality factors of up to 3.8 × 10 5 at 980 nm and 5.7 × 10 5 at 1550 nm in undoped microrings. In erbium-and ytterbium-doped(More)
A single-mode, electroactive waveguiding platform capable of measuring spectroelectrochemical responses of surface-adsorbed redox-active molecules over a broad spectral bandwidth has been created. This new planar wave-guide spectrometer is a combination of the previously developed electroactive integrated optical waveguide (EA-With the use of a commercially(More)
By sequentially pushing micro-beads towards and away from a sensing surface, we show that ultrasonic radiation forces can be used to enhance the interaction between a functionalized glass surface and polystyrene micro-beads, and identify those that bind to the surface by illuminating bound beads using an evanescent field generated by guided light. The(More)
  • James S Wilkinson, E D H Axelrod, R M Hellen, Fulbright, Total, J R Lakowicz +33 others
  • 2006
Planar optical waveguides are well established components for the interrogation of chemical processes at surfaces with, for example, total internal reflection fluorescence (TIRF) elements having a long pedigree [1] and surface plasmon resonance (SPR) sensors finding widespread use in biomolecular research [2]. The most important attributes of these devices(More)
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